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  • 1
    ISSN: 1432-1440
    Keywords: Abbreviations ALL Acute lymphoblastic leukemia ; BMT Bone marrow transplantation ; CTL Cytotoxic T-lymphocytes ; IL Interleukin ; MHC Major histocompatibility ; MRD Minimal residual diseaseIntroductionObjective ; The purpose of this protocol is to induce a specific cellular immune reaction after autologous bone marrow transplantation (BMT) by vaccination with human leukocyte antigen (HLA) B13 transfected autologous leukemic cells in children with high-risk relapse of acute lymphoblastic leukemia (ALL). Specific cytotoxic T-lymphocytes (CTL) will be expanded in vivo by low-dose interleukin-2 (IL-2). The expression vector used is the pcDNA3 HLA-B13 plasmid ; driven by a cytomegalovirus promoter. Leukemic cells are transfected by electroporation/ballistomagnetic transfer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 138 (1982), S. 263-265 
    ISSN: 1432-1076
    Keywords: Invasive aspergillosis ; CNS-leukemia ; amphotericin B-5 ; Fluorocytosine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A favourable outcome was observed in a 12 year-old boy who developed invasive pulmonary and cerebral aspergillosis during antineoplastic treatment for central nervous system relapse of acute lymphoblastic leukemia. Combination therapy with amphotericin B and 5-Fluorocytosine led to complete regression of pulmonary infiltrates. Despite enlargement of the cerebral lesion monitored by computerized tomography, no viable fungi were found in the completely resected abscess after a 4 weeks' course of antifungal treatment preceeding neurosurgery. Histological examination confirmed the diagnosis of an aspergillotic abscess. The initially severe neurological symptoms disappeared after successful surgery. Aspergillus fumigatus was detected in the soil of a potted ornamental plant in the mother's living room, suggesting that this might have been the source of the infectious agent.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 459-459 
    ISSN: 1435-2451
    Keywords: Tensile rod fixation ; Defect osteosynthesis ; Defektosteosynthese ; Zugstangenfixateur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wesentliches Problem einer Defektosteosynthese ist ihre Instabilität, hervorgerufen durch Biegebelastung der Steinmannägel in „falscher” Richtung zum Hauptkraftfluß. Im Zugstangenfixateur werden die Implantate in Zuganker umfunktioniert, in dem ihre Richtung der des Kraftflusses angenähert wird. Sie entstehen durch schräg zur Knochenachse gesetzte Schanz'sche Schrauben. Der Stabilitätsgewinn ist 5–20mal höher als bei konventionellen Montagen.
    Notes: Summary It is very difficult to stabilize a defective osteosynthesis of the lower extremity, which is necessary to prevent bone infection. Mainly responsible for the instability is the lack of bending stability of the transosseous nails which are loaded across their axle. In a newly developed model called the “tensile rod fixateur” (Labitzke and Henze 1979–1980) Schanz screws function as tensile rods. A defective osteosynthesis treated with this principle shows 5–20 times more stability than those treated in a conventional way.
    Type of Medium: Electronic Resource
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