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  • 1
    Electronic Resource
    Electronic Resource
    Pulmonary tuberculosis due to bacille Calmette-Guérin (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 787-790 
    Details
    ISSN: 1432-1440
    Keywords: Bladder cancer ; Bacille Calmette-Guérin immunotherapy ; Bacille Calmette-Guérin tuberculosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunotherapy using bacille Calmette-Guérin (BCG) has gained increasing acceptance in the management of superficial bladder cancer. Systemic reactions after intravesical instillation of BCG are rare. However, when the therapy is complicated, the lung often becomes involved. Since the pathogenesis of lung infiltrates after immunotherapy is unknown, we report on a patient who developed a lung infiltrate after receiving BCG immunotherapy for bladder cancer. The infectious etiology was established by culture confirmation of a BCG strain in the broncheoalveolar lavage fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190319
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the mode of action of intravesical bacillus Calmette-Guérin: in vitro characterization of BCG-activated killer cells (1994)
    Springer
    Urological research 22 (1994), S. 185-190 
    Details
    ISSN: 1434-0879
    Keywords: BCG vaccine ; Immunotherapy ; Bladder cancer ; Cytotoxicity ; NK-cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previously we had shown that, upon activation with viable bacillus Calmette-Guérin (BCG), peripheral blood mononuclear cells (PBMNC) could be rendered cytotoxic against otherwise insensitive natural killer (NK)-resistant bladder cancer cell lines. This phenomenon had been termed the BCG-activated killer (BAK) cell phenomenon. By means of depletion and enrichment procedures of mononuclear cell subpopulations derived from BCG-activated PBMNC we further characterized the cytolytic BAK effector cells functionally in an in vitro cytotoxicity assay against the bladder carcinoma cell line BT-A and phenotypically in their pathway of activation. Neither macrophages nor CD4+ T-helper/inducer cells exerted cytotoxic BAK activity. This cytotoxicity was restricted to the CD8-CD56+ subpopulation of T-cytotoxic/NK cells. Furthermore, activation of BAK cells via interferon gamma (IFN-γ) was evidenced by the complete inhibition of BAK cell generation with an IFN-γ antibody.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571848
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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