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  • 1
    Electronic Resource
    Electronic Resource
    Morgendlicher Blutdruckanstieg: vor oder nach dem Aufwachen? (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 320-323 
    Details
    ISSN: 1432-1440
    Keywords: Blood pressure ; Hypertension ; Sleep ; Waking up ; Antihypertensive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The coincidence of the circadian peak of cardiovascular events with the morning blood pressure rise suggests causal connections. Rapidly acting antihypertensives taken before getting up may attenuate the increase early enough, if the onset does not occur before awakening. In 111 normotensives and in 109 subjects with untreated essential hypertension ambulatory blood pressure monitoring was performed to study whether the onset of the blood pressure rise occurs before or after waking up. The individual 24 h blood pressure profiles obtained by intermittent readings at intervals of 15 minutes were synchronized by the time of waking up. The resulting blood pressure curves showed no substantial blood pressure rise during sleep, but steep increases after awakening: Within the first hour after waking up blood pressure increased from 107.3+11.4/62.3±9.6 mm Hg (mean+sd) to 121.4±16.0/75.3+12.6 mm Hg in normotension and from 124.7+16.0/72.7+12.2 mm Hg to 140.3+17.2/84.5+13.3 mm Hg in hypertension. The velocity of this increase was dependent on the lag between waking up and getting up. There was no phase difference between early morning blood pressure and heart rate rises. Thus to attenuate the morning blood pressure increase, rapidly acting drugs after awakening may be considered instead of long acting antihypertensives administered prior to sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649023
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diurnal variations of blood pressure in shift workers during day and night shifts (1989)
    Springer
    International archives of occupational and environmental health 61 (1989), S. 463-466 
    Details
    ISSN: 1432-1246
    Keywords: Shift work ; Night shift ; Blood pressure ; 24-h blood pressure monitoring ; Circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The dependence of blood pressure upon internal rhythms and the short-term effects of shift rota on the blood pressure were investigated in shift workers. Blood pressure was measured every 30 min using automatic recorders for 24 h in 17 physically working men in a chemical factory during their morning and night shifts. Mean 24-h blood pressures were identical in the morning and night shifts. There were no differences of the mean blood pressure between the respective sleeping phases or between the working periods. The amplitudes of circadian blood pressure variations were equal. There was a phase difference of 8 h corresponding to the lag between the working periods. At this 8-h lag the hourly means of the 24-h blood pressure were closely correlated (r = 0.69). Comparisons of 24-h blood pressure profiles during the first and last days of a night shift week showed that the effects of night work on the blood pressure were already fully developed within the first 24h (r = 0.86). Thus the diurnal variations of the blood pressure are determined by the working and sleeping periods and largely independent of endogenous rhythm. There is no short-term alteration of the mean 24-h blood pressure after shift rota.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386480
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma dopamine-β-hydroxylase activity and the pressor effect of dopamine infusion in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 197-200 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine-β-hydroxylase ; dopamine infusion ; blood pressure ; plasma ; man ; inter-individual variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to study the function of dopamine-β-hydroxylase (DBH) in human plasma, dopamine, its natural substrate, was infused intravenously in 22 healthy volunteers. Their plasma DBH activities showed great interindividual variations (31–301 units/ml). The infusion rates of dopamine required to increase systolic blood pressure (BP) by 30 mm Hg differed considerably between the subjects, and ranged from 3,0 to 11,6 µg/kg/min. No correlation could be shown between the various dopamine doses and individual plasma levels of DBH. It was concluded, therefore, that plasma DBH in the blood stream was enzymatically inactive. Experiments with human plasma DBH in vitro also support this interpretation. Consequently, interindividual differences in the effects on BP during dopamine infusion cannot be due to pressor effects of noradrenaline synthesized by plasma DBH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558329
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A comparison of catecholamine concentrations and dopamine-β-hydroxylase activities in plasma from normotensive subjects and from patients with essential hypertension at rest and during exercise (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 561-565 
    Details
    ISSN: 1432-1440
    Keywords: Plasmakatecholamine ; Dopamin-β-Hydroxylase ; Essentielle Hypertonie ; Körperliche Belastung ; Plasma catecholamines ; Dopamine-β-hydroxylase ; Essential hypertension ; Physical exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 8 normotensive subjects and in 8 patients with essential hypertension total catecholamine content and dopamine-β-hydroxylase (DBH) activity in plasma were measured at rest and during physical exercise. Catecholamine levels at rest were significantly higher in the hypertensive than in the normotensive persons whereas the 2 groups of subjects did not differ in DBH activity at rest. At a work load of 150 watts there was a more pronounced increase of the catecholamine concentrations and of the DBH activity in the hypertensive patients than in the normotensives. One may conclude from the data that there is an increased sympathetic nerve activity in patients with essential hypertension.
    Notes: Zusammenfassung Bei 8 Normotonikern sowie bei 8 Patienten mit essentieller Hypertonie wurden die Konzentrationen der Gesamtkatecholamine und die Aktivität der Dopamin-β-Hydroxylase (DBH) im Plasma unter Ruhebedingungen und während körperlicher Belastung gemessen. Bei den Hypertonikern waren die Ruhewerte der Katecholamine signifikant höher als bei den Normotonikern, während die DBH-Aktivität unter diesen Bedingungen bei beiden Gruppen gleich war. Bei einer Ergometerbelastung von 150 Watt stiegen die Katecholaminspiegel und die DHB-Aktivität bei den Hochdruckkranken stärker an als bei den Probanden mit normalem Blutdruck. Aus den Untersuchungsergebnissen kann man schließen, daß bei Patienten mit essentieller Hypertonie eine erhöhte Aktivität sympathischer Nerven besteht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01619571
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    Paper (German National Licenses)
    Fulltext
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