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  • 1
    Electronic Resource
    Electronic Resource
    Bay K 8644, a voltage-sensitive calcium channel agonist, facilitates secretion of atrial natriuretic polypeptide from isolated perfused rat hearts
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 138 (1986), S. 1170-1176 
    Details
    ISSN: 0006-291X
    Keywords: [abr] ANP; atrial natriuretic polypeptide ; [abr] HP-GPC; high performance gel permeation chromatography ; [abr] RIA; radioimmunoassay ; [abr] S.E.; standard error ; [abr] α-hANP; α-human atrial natriuretic polypeptide ; [abr] α-rANP; α-rat atrial natriuretic polypeptide ; [abr] β-rANP; β-rat atrial natriuretic polypeptide ; [abr] γ-rANP; γ-rat atrial natriuretic polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(86)80405-3
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bay K 8644, a voltage-sensitive calcium channel agonist, facilitates secretion of atrial natriuretic polypeptide from isolated perfused rat hearts
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 138 (1986), S. 1170-1176 
    Details
    ISSN: 0006-291X
    Keywords: [abr] ANP; atrial natriuretic polypeptide ; [abr] HP-GPC; high performance gel permeation chromatography ; [abr] RIA; radioimmunoassay ; [abr] S.E.; standard error ; [abr] α-hANP; α-human atrial natriuretic polypeptide ; [abr] α-rANP; α-rat atrial natriuretic polypeptide ; [abr] β-rANP; β-rat atrial natriuretic polypeptide ; [abr] γ-rANP; γ-rat atrial natriuretic polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(86)80405-3
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Alterations in neutral amino acid transport across the blood-brain barrier in hepatic failure (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 11-18 
    Details
    ISSN: 1433-8580
    Keywords: Blood-brain barrier ; Neutral amino acid ; Hepatic failure ; Amino acid transport into the brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accelerated transport of the blood neutral amino acids into the brain in encephalopathic patients with fulminant hepatitis and advanced liver cirrhosis was demonstrated not only by determining the cerebrospinal fluid (CSF) aminogram but also by calculating the predicted velocity of the amino acid transport through the blood-brain barrier. Significant elevation in CSF aromatic amino acid (AAA) and methionine levels was observed in the encephalopathic patients. Arousal from hepatic encephalopathy by drip infusion of a branched chain amino acid (BCAA)-enriched solution was obtained coincidentally with the elevated BCAA levels and diminished concentrations of AAA and methionine in CSF. These clinical observations were confirmed experimentally in rats treated with carbon tetrachloride (CCl4) andd-galactosamine by obtaining the elevation of neutral amino acid contents in the brain and the slight increase in the brain uptake index (BUI) of a radiolabeled amino acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851759
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Glucagon-like polypeptide and insulin contents in the brain from acute hepatic failure dogs (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 203-208 
    Details
    ISSN: 1433-8580
    Keywords: Acute hepatic failure ; Insulin ; Glucagon ; Glucagon-like peptides ; Blood-brain barrier ; Thalamus-hypothalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin contents in the thalamus-hypothalamus were significantly increased in acute hepatic failure dogs treated with dimethylnitrosamine. Glucagon immunoreactivity (GI) contents also tended to increase in the same portion of the brain. However, insulin and GI contents in the cerebral cortex and midbrain did not rise. Glucagon-like immunoreactivity (GLI) contents were much higher than GI in all the brain regions tested, but the levels were not significantly altered in hepatic failure dogs. A simultaneous infusion of insulin and glucagon to hepatic failure dogs failed to produce an elevation of insulin, GI and GLI contents even in the thalamus-hypothalamus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852045
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Expressions of a calcium-binding protein (spot35/calbind in-D28k) in mouse olfactory cells: Possible relationship to neuronal differentiation (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 105-109 
    Details
    ISSN: 1434-4726
    Keywords: Immunohistochemistry ; Olfactory epithelium ; Cell growth ; Proliferating cell nuclear antigen ; Olfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used immunohistochemistry to investigate the expression of spot35/calbindin-D28k (calbindin) in mouse olfactory epithelium during development. Cell stages of immunopositive olfactory cells were determined by comparing the levels of proliferating cell nuclear antigen (PCNA). Calbindin-positive cells were abundant in the middle layer of the epithelium of animals before 2 weeks of age and gradually diminished during development. Only low levels were detectable near the basement membrane in the adult. Changes of calbindin-positive cells in terms of number and distribution were apparently compatible with localization changes of premature olfactory cells. PCNA overlapped calbindin in the nasal mucosa at lower magnifications on stained serial sections and immunohistochemical double staining revealed that calbindin-mmunoreactive cells were located mainly just above PCNA-immunoreactive cells in the basal layer of the epithelium. This indicated that calbindin is expressed postmitotically in immatureolfactory cells and is lost by mature cells. These findings suggest that calbindin might support the maturation of the olfactory cells, such as the projection of the neuronal processes, by stabilizing intracellular calcium ions in immature cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526190
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Olfactory disturbances caused by the anti-cancer drug tegafur (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 48-52 
    Details
    ISSN: 1434-4726
    Keywords: Tegafur ; Bromodeoxyuridine ; Proliferating cell nuclear antigen ; Immunohistochemistry ; Cell mitoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Olfactory disturbances induced by the anticancer drug tegafur were studied in separate clinical and experimental investigations. Five patients with olfactory dysfunction after tegafur were studied and were found to have normal endoscopic findings of the olfactory cleft mucosa. The average period for drug administration was 22 months. Recovery from the olfactory disturbance was poor and biopsy of the olfactory mucosa revealed severely degenerated epithelium. In experimental studies in a guinea pig animal model, effects of oral tegafur on mitotic cells in the olfactory epithelium were examined using bromodeoxyuridine (BrdU) uptake as index. At the conclusion of 3 weeks' treatment, no pronounced morphological changes were seen, but the number of BrdU-incorporating cells decreased in proportion to the dose of tegafur used. Following long-term administration of tegafur 18 months, mitotic cells reacting to BrdU or proliferating cell nuclear antigen had virtually disappeared, indicating persistent inhibition of mitotic cell activity. Morphological changes present included decreased olfactory cell numbers, loss of cells in areas just above basal cells and degeneration of the mucous layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171440
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    Paper (German National Licenses)
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