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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 415 (1989), S. 103-113 
    ISSN: 1432-2307
    Keywords: Renal clear cell carcinoma ; Blood vessels ; Angiogenesis ; Corrosion casts SEM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The vascular system of human renal clear cell carcinoma was studied using light microscopy of silicon rubber-injected specimens and scanning electron microscopy of conventionally prepared tissue and vascular corrosion casts. The system was found to exhibit the following features: (1) a well developed superficial vascular coat showing different pattern on the anterior and on the posterior side of the tumour, (2) an internal vascular network composed of altered and displaced preexisting vessels, numerous newly formed ones and those recruited from adjacent structures, (3) quantitative prevalence of dilated veins and distended capillaries, (4) a remarkable proliferative reaction of stellate veins, (5) characteristic features of the intratumour vasculature in the form of avascular nodules surrounded by basket-like capillary plexuses and separated by well vascularized “septa”, (6) a relatively less dense vascularization of central tumour areas, frequently exhibiting necrotic foci, and the highest density of vessels in areas close to the superficial vascular coat, and (7) morphological evidence for a continuous remodelling of the tumour vasculature. The observed patterns of the vascular system seem to provide a pathway for further tumour expansion.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 100 (1981), S. 271-283 
    ISSN: 1432-1335
    Keywords: Cancer of the larynx ; Blood vessels ; Microcorrosion casts ; SEM ; Kehlkopfkarzinom ; Blutgefäße ; Plastik-Korrosion-Präparate ; Rasterelektronenmikroskopie (REM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit Hilfe der REM wurde die Morphologie der Innenabdrucke von Blutgefäßen bei Kehlkopfkarzinom untersucht. Als bösartige Geschwulst produziert es TAF und ist somit fähig, den Prozeß der Neoangiogenesis in Gang zu setzen. Die größten Unterschiede in den Replika-Mustern des Endothels im Vergleich mit denjenigen von normalem Gewebe wurden bei Kapillaren, Venolen und Venen festgestellt. In allen Zonen des Kehlkopfkarzinoms machen Kapillargefäße den größten Anteil des Blutgefäßlagers aus. Auch erweisen sie die stärkste morphologische Differenzierung sowohl im Fall von blind endenden, kolbenförmig im distalen Abschnitt erweiterten Röhrchen als auch bei Schlingen, die durch Gefäße recht verschiedenen Durchmessers gebildet werden, und deren Arme während ihres Wachstums einer oft sehr starken Verwindung und zusätzlichen Biegungen unterliegen. Die sich neu bildenden Kapillargefäße, die vor allem dem veno-kapillaren Gefäßlager der Umgebung entstammen, entsprechen dem Typ embryonaler Blutgefäße. Deshalb ist es sehr wahrscheinlich, daß der durch aktives Einwirken von TAF hervorgerufene Prozeß der Neoangiogenese im Prinzip einer Repetition der Mechanismen der embryonalen Angiogenese gleichkommt.
    Notes: Summary Morphology of blood vessels in cancer of the larynx, which as other solid tumors has great neoangiogenic abilities, was studied on microcorrosion casts in SEM. Most evident changes of the endothelial patterns were seen on the casts of capillaries, venules, and veins. Capillaries, especially the newly formed, are the most numerous constituent of the vasacular bed in all zones of cancer of the larynx. These vessels exhibit great morphological differentiation varying from the single, blind-ended pipes via relatively long hairpin loops spirally twisted in the long axis, to strongly spiralled and convoluted loops, resembling pseudoglomeruli. The newly formed capillaries deriving predominantly from the host's capillaries, venules, and veins have an embryonal character. It seems resonable to presume that the neoangiogenesis process triggered by active influence of the tumor angiogenesis factor, is in principle, a repetition of the mechanism of the embryonal angiogenesis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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