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  • 1
    ISSN: 0014-5793
    Keywords: Bradykinin ; Cell volume ; Intracellular calcium ; Na^+/H^+ exchanger ; ras oncogene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Myelin lipids ; White matter lipids ; Glycosphingolipids ; Cerebrosides ; Sulfatides ; Micromethod ; Fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde eine Mikromethode zur Bestimmung der Fettsäurezusammensetzung der myelintypischen Glykosphingolipide (Cerebroside und Sulfatide) entwickelt, welche für entsprechende Untersuchungen bei verschiedenen neurologischen Erkrankungen, insbesondere Entmarkungskrankheiten, eingesetzt werden kann. Ausgehend von 1 g Gewebsmaterial werden die Lipide extrahiert, die Phospholipide an aktiviertem Florisil abgetrennt und die Glykolipide dünnschichtchromatographisch in je 2 Cerebrosid- und Sulfatidfraktionen aufgetrennt. Diese können dann einzeln untersucht werden. Die Ergebnisse der Fettsäureanalysen von 13 autoptisch gewonnenen normalen Gehirnproben erwachsener Personen besitzen nur eine geringe Streubreite, was besonders für die langkettigen Fettsäuren gilt. Die Befunde mit unserer Mikromethode stehen in guter Übereinstimmung mit den Werten anderer Autoren.
    Notes: Summary A micromethod for the investigation of the fatty acid composition of myelin glycosphingolipids (cerebrosides and sulfatides) suitable for general application in the investigation of neurological disorders, especially demyelinating diseases, is presented. Using the lipids extracted from 1 g of material these are freed of phospholipids by Florisil column chromatography and separated by thin-layer chromatography into 2 cerebroside and sulfatide fractions which are analyzed individually. The results obtained from the white matter of 13 normal adult brains are distributed within a narrow range which is most pronounced for the group of long chain fatty acids. Our results also agree with those quoted from literature.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Cell volume ; Intracellular pH ; ras oncogene ; Calcium oscillations ; Cell membrane potential ; Bradykinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In NIH 3T3 fibroblasts expressing the Ha-ras oncogene (+ras) bradykinin leads to sustained oscillations of cell membrane potential due to oscillations of intracellular Ca2+ with subsequent activation of Ca2+-sensitive K+ channels. In cells not expressing the oncogene (-ras), bradykinin leads only to a single transient hyperpolarization of the cell membrane. The present study has been performed to elucidate the possible interaction of cell volume, intracellular pH and bradykinin-induced oscillations of the cell membrane potential. Bradykinin leads to cell shrinkage and intracellular alkalinization of both +ras cells and −ras cells. Inhibition of Na+/H+ exchanger by HOE 694 abolishes the bradykinin-induced alkalinization but does not significantly interfere with the bradykinin-induced oscillations of cell membrane potential. In contrast, prevention of bradykinin-induced cell shrinkage by simultaneous reduction of extracellular osmolarity blunts the oscillations. Thus, cell shrinkage stimulates bradykinin-induced oscillations of cell membrane potential. On the other hand, cell shrinkage alone does not elicit oscillations unless, in addition, Ca2+ entry is stimulated by ionomycin.
    Type of Medium: Electronic Resource
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