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  • 1
    Electronic Resource
    Electronic Resource
    Selektive Analyse von Bewegungsrichtung und Geschwindigkeit in der visuellen Wahrnehmung des Menschen (1973)
    Springer
    Psychological research 36 (1973), S. 267-296 
    Details
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Description / Table of Contents: Zusammenfassung l. Die Methode der selektiven Adaptation wurde auf die Parameter „Bewegungsrichtung“ und „Geschwindigkeit“ bei der Wahrnehmung von bewegten Mustern angewendet. 2. Adaptation war dabei definiert als die Veränderung in der minimalen Entdeckungszeit für Translationsbewegungen (tachistoskopische Darbietung) in Abhängigkeit von den Adaptationsreizen (bei Variation von Bewegungsrichtung und Geschwindigkeit). 3. Mit dieser Methode konnten für die Wahrnehmungsanalyse von Eigenschaften bewegter optischer Muster informationsselektive Verarbeitungssysteme ausgegliedert werden, die bewegungsrichtungs- und geschwindigkeitsempfindlich sind. Dadurch sind Möglichkeiten aufgezeigt, die Struktur der afferenten Bewegungswahrnehmung des Menschen zu analysieren. 4. Die Ergebnisse konnten zu den vorliegenden Daten der Neurophysiologie des Bewegungssehens in Beziehung gesetzt werden.
    Notes: Summary 1. The method of selective (differential) adaptation was applied to the parameters direction of movement and velocity in the perception of moving patterns. 2. Adaptation was determined by measuring changes in the minimum duration of tachistoscopic presentations needed for the perception of translational movements as a function of the applied stimuli (including variations in direction of movement and velocity). 3. This approach enabled the selective stimulus processing systems for direction of movement and velocity to be separated, and may ultimately allow the structure of human afferent movement perception to be analyzed. 4. The results are discussed in connection with the neurophysiology of movement perception.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00424480
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  • 2
    Electronic Resource
    Electronic Resource
    Effets du groupement sur l'activité et la ponte du DoryphoreLeptinotarsa decemlineata Say (1961)
    Springer
    Insectes sociaux 8 (1961), S. 109-123 
    Details
    ISSN: 1420-9098
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Summary One of us has previously noted: On the one hand that the mean fecundity of females grouped in a breeding cage is reduced and that the eggs are deposited else here than on the branch of the potato plant; on the other hand that grouping diminishes the longevity and especially the food consumption of the insects. We also established a close correlation between the individual food consumption and the fecundity of the females. We resumed the experimental and stimultaneous study of these various factors with lots of 5 grouped females and 5 isolated females. The biometric analysis shows that the “regression” of longevity has a greater meaning than that of food consumption; but the difference between the lots of the isolated and those of the grouped is negligible in respect to longevity. On the contrary, the food consumption of the two binds of lots is markedly different; this explains in part the great difference in fecundity observed: the mean fecundity of the isolated females is 1.440 eggs, and that of the grouped ones 416 eggs. Taking into account the difference in fecundity due to the difference in food consumption, the first is reduced statistically from 1.023 to 677 eggs, the latter can be attributed in a significant manner to the effect of grouping. This phenomenon does not result from aneffet de masse, but presumably from the effect sensorial stimuli inhibiting certain physiological functions in a species that is typically solitary.
    Notes: Résumé Il est établi expérimentalement et analysé biométriquement que des femelles groupées deL. decemlineata présentent, par rapport à des femelles isolées: - une longévité un peu plus grande mais non significativement différente; - une consommation beaucoup plus faible; - une fécondité considérablement réduite. La différence de la fécondité n'est pas seulement due à la différence de consommation, mais vraisemblablement à des facteurs inhibiteurs intrinsèques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02225736
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  • 3
    Electronic Resource
    Electronic Resource
    Marine lipids normalize cholesteryl ester transfer in IDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 487-491 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Marine lipids ; cholesteryl ester transfer ; diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with insulin-dependent diabetes mellitus (IDDM) have a pathological increase in cholesteryl ester transfer (CET) that enriches the apolipoprotein B-containing lipoproteins with cholesteryl ester and increases their atherogenicity. Since we have shown earlier that omega-3 (n-3) fatty acids present in marine lipids normalize both CET and lipoprotein composition in non-diabetic patients with hypercholesterolaemia, we sought to determine whether the same beneficial effects could be achieved in nine normolipidaemic (triglycerides 1.10; cholesterol 4.94, high density lipoprotein 1.10 mmol/l) IDDM patients (fructosamine 424 ± 156; normal 174–286 μmol/l) treated for 2 months with n-3 fatty acids (4.6 g/day). Before treatment, CET measured by both mass and isotopic assays was abnormally accelerated (p 〈 0.001). While marine lipids modestly decreased triglyceride levels ( − 14 %; p 〈 0.05), CET fell dramatically in all subjects (mass assay: − 97 % at 1 h; isotopic assay: − 58 %; p 〈 0.001) to below control levels with no change in glycaemic control (fructosamine 408 ± 103 μmol/l). The mass of cholesteryl ester transfer protein paradoxically increased significantly (pre-treatment: 2.04 ± 0.86 vs post-treatment 2.48 ± 0.97 μg/ml; p 〈 0.05). Since it is believed that accelerated CET promotes the formation of atherogenic cholesteryl ester-enriched apo B-containing lipoproteins, the capacity of marine lipids to reverse this functional abnormality without altering glycaemic control suggests that these agents may have an adjunctive role to play in the nutritional therapy of IDDM. [Diabetologia (1996) 39: 487–491]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400682
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  • 4
    Electronic Resource
    Electronic Resource
    Marine lipids normalize cholesteryl ester transfer in IDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 487-491 
    Details
    ISSN: 1432-0428
    Keywords: Marine lipids ; cholesteryl ester transfer ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with insulin-dependent diabetes mellitus (IDDM) have a pathological increase in cholesteryl ester transfer (CET) that enriches the apolipoprotein B-containing lipoproteins with cholesteryl ester and increases their atherogenicity. Since we have shown earlier that omega-3 (n-3) fatty acids present in marine lipids normalize both CET and lipoprotein composition in non-diabetic patients with hypercholesterolaemia, we sought to determine whether the same beneficial effects could be achieved in nine normolipidaemic (triglycerides 1.10; cholesterol 4.94, high density lipoprotein 1.10 mmol/l) IDDM patients (fructosamine 424±156; normal 174–286 Μmol/l) treated for 2 months with n-3 fatty acids (4.6 g/day). Before treatment, CET measured by both mass and isotopic assays was abnormally accelerated (p〈0.001). While marine lipids modestly decreased triglyceride levels (−14%; p〈0.05), CET fell dramatically in all subjects (mass assay: −97% at 1 h; isotopic assay: −58%; p〈0.001) to below control levels with no change in glycaemic control (fructosamine 408±103 Μmol/l). The mass of cholesteryl ester transfer protein paradoxically increased significantly (pre-treatment: 2.04±0.86 vs post-treatment 2.48±0.97 Μg/ml; p〈0.05). Since it is believed that accelerated CET promotes the formation of atherogenic cholesteryl ester-enriched apo B-containing lipoproteins, the capacity of marine lipids to reverse this functional abnormality without altering glycaemic control suggests that these agents may have an adjunctive role to play in the nutritional therapy of IDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400682
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  • 5
    Electronic Resource
    Electronic Resource
    Prognostic factors in medullary thyroid carcinoma: evaluation of 741 patients from the German Medullary Thyroid Carcinoma Register (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 7-12 
    Details
    ISSN: 1432-1440
    Keywords: Medullary thyroid carcinoma ; Prognostic factors ; Sporadic and familial form ; Age ; Sex ; Tumor stage at diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 741 patients with medullary thyroid carcinoma diagnosed between 1967 and 1991 was carried out by members of the German Medullary Thyroid Carcinoma Study Group to evaluate prognostic factors. A total of 559 patients (75%) were considered to have sporadic disease, and 182 (25%) had the familial type. The sex ratio (male to female) was 1:1.4 in sporadic disease patients, and the mean age at diagnosis was 45.9 years (range 5-81 years). For familial disease patients the sex ratio was 1:1.1, and the mean age at diagnosis was 33.4 (range 5–77 years). The follow-up time for 630 patients ranged from 1 month to 20.8 years (mean 13.0 years). The overall adjusted survival rate was 86.7% at 5 years and 64.2% at 10 years. In a univariate analysis the stage of disease at diagnosis, age, sex, and type of disease (sporadic, familial) were relevant prognostic factors, with a better prognosis for young female patients with familial disease and diagnosed at an early stage. In a multivariate proportional hazards analysis, the difference in the survival rate of patients with familial disease versus those with the sporadic form disappeared, while prognostic information provided by age and sex was still significant. The poorer prognosis of patients with sporadic medullary thyroid carcinoma may be related to the patients' older age at detection and more advanced tumor stage at diagnosis. There seems to be no difference in biological behavior between tumors of the sporadic and those of the familial type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210956
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of fiber, xylitol and fructose in enteral formulas on glucose and lipid metabolism in normal subjects (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 290-293 
    Details
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Enteral formula ; Fructose ; Insulin ; Xylitol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To verify the benofit of nonglucose carbohydrates and fiber in enteral formula diets we studied the postprandial metabolism of eight healthy subjects after the intake of two helpings (25 g carbohydrates each) of five commonly used enteral formulas over 4 h. There were no significant differences in postprandial concentrations of blood glucose among the formulas. The area under the curve of postprandial insulin values, however, was significantly smaller after consumption of the fructose-containing formula (1948±285 μU min ml−1, P〈0.05) than after fiber-free (3222 ±678 μU min ml−1) or two fiber-containing products (2664±326 μU min ml−1, P〈0.05; and 3040±708 μU min ml−1, P〈0.05). The insulin area of the xylitol-containing formula (2307±364 μU min ml−1) was significantly smaller compared to the fiber-free product (P〈0.05). In addition, we found the postprandial increase in triglycerides to be significantly higher after the xylitol-containing formula (from 0.93±0.14 to 1.25±0.22 mmol/1) than after the fiber-free product (from 0.82±0.13 to 0.97±0.16 mmol/1, P〈0.05) or the two fiber-containing products (from 0.88±0.16 to 0.96±0.18 mmol/1, P〈0.05; and from 0.80±0.08 to 0.95±0.10 mmol/l, P〈0.05). We conclude that a patient with type 11 diabetes may benefit from replacing glucose and glucose-equivalent carbohydrates with fructose or xylitol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184729
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of LDL apheresis on progression of coronary artery disease in patients with familial hypercholesterolemia (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 858-863 
    Details
    ISSN: 1432-1440
    Keywords: Familial hypercholesterolemia ; LDL apheresis ; Coronary artery disease ; Quantitative angiography ; Visual estimation of coronary atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the effect of extracorporal lipid-lowering therapy by low-density lipoprotein (LDL) apheresis on coronary artery disease in a population characterized by early development and rapid progression of atherosclerosis. We treated 32 patients aged between 15 and 63 years with drug-refractory familial hypercholesterolemia, treated once a week by immuno-specific LDL apheresis for 3 years in a controlled prospective and non-randomized trial; 25 patients (14 females and 11 males) completed the study. Noninvasive data were obtained by physical examination, 12-lead ECG and exercise testing. Invasive cardiological data were obtained by cardiac catheterization according to a standardized protocol in four cardiological centers. Left ventricular ejection fraction was calculated using planimetry. Coronary stenoses were measured quantitatively in 23 defined coronary segments by a panel of four investigators with an electronic digital caliper. In addition, overall coronary atherosclerosis was visually qualified. Final decisions on a classification into one of three groups (regression, no change, progression) of coronary atherosclerosis were based on panel consensus. Six cardiac events occurred throughout the study: percutaneous transluminal coronary angioplasty in one patient, coronary bypass grafting in three and two deaths. Statistical analysis of exercise testing yielded no significant change for maximum power and work capacity during the study period. Hemodynamic data revealed no significant change; mean ejection fraction was calculated as 65.8 ± 15.9% at study entry and 67.0 ± 12.7% at completion. Quantitative measurement of 111 circumscribed coronary stenoses showed a mean stenosis degree of 45 ± 26% at entry cineangio-film and 43 ± 22% at final cineangio-film demonstrating no significant change. Eight localized stenoses showed a regression of more than 10% and 11 stenoses a progression of more than 10%. Panel consensus decision for overall coronary atherosclerosis resulted in regression in no patients, no change in 16, questionable progression in 3, definite progression in 5, and undecided in one. We conclude that specific LDL-apheresis therapy can be used effectively for primary and secondary prevention of coronary artery disease in patients with familial hypercholesterolemia. Its beneficial effect was the prevention of further progression of coronary artery disease in the majority of the study population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190741
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist (1995)
    Springer
    European journal of clinical pharmacology 49 (1995), S. 115-119 
    Details
    ISSN: 1432-1041
    Keywords: Losartan ; Cimetidine ; pharmacokinetics ; plasma renin activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract This was a 2-period randomized, crossover study in 8 healthy males to determine the effects of cimetidine (400 mg q.i.d. for 6 days) on the pharmacokinetics and pharmacodynamic effects of the angiotensin II receptor antagonist, losartan (100 mg). Cimetidine increased the AUC for losartan 18% without affecting the AUC for E-3174, the active metabolite of losartan. The increase in plasma renin activity following losartan was not affected by cimetidine (maximum mean increases 12.6 and 12.1 ng Ang I·ml−1·h−1 without and with cimetidine, respectively). These results indicate that cimetidine does not appear to alter the pharmacokinetics or pharmacodynamics of losartan to a clinically significant extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192369
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  • 9
    Electronic Resource
    Electronic Resource
    On the validity of free hormone measurements
    Amsterdam : Elsevier
    Analytical Biochemistry 132 (1983), S. 174-182 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(83)90444-X
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  • 10
    Electronic Resource
    Electronic Resource
    Experiments to the problem of interocular transfer
    Amsterdam : Elsevier
    Acta Psychologica 24 (1965), S. 81-90 
    Details
    ISSN: 0001-6918
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0001-6918(65)90007-7
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