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  • Free-living amebas  (3)
  • Extraocular muscles  (2)
  • Brain  (1)
  • Cerebral Edema  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Granulomatous Amebic Encephalitis presenting as a cerebral mass lesion (1980)
    Springer
    Acta neuropathologica 51 (1980), S. 85-91 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Acanthamoeba ; Amebic encephalitis ; Corticosteroids ; Free-living amebas ; Immunosuppression ; Intracranial mass ; Naegleria
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Clinical and brain biopsy or autopsy findings in six patients with Granulomatous Amebic Encephalitis (GAE) due toAcanthamoeba sp. were characterized by focal neurological symptoms, increased intracranial pressure, and focal neuroradiological findings. Craniotomies were performed because of the diagnostic possibility of a mass lesion such as a brain tumor or abscess. In four patients, frozen sections demonstrated free-living amebas. GAE may present as an acute or subacute intracerebral mass lesion with signs and symptoms of focal brain disease and should be differentiated from viral, bacterial, fungal, and other protozoal encephalitides.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690448
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  • 2
    Digitale Medien
    Digitale Medien
    Granulomatous encephalitis, intracranial arteritis, and mycotic aneurysm due to a free-living ameba (1980)
    Springer
    Acta neuropathologica 49 (1980), S. 7-12 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Free-living amebas ; Encephalitis ; Granuloma ; Acanthamoeba ; Naegleria ; “Mycotic aneurysm”
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Primary amebic meningoencephalitis and granulomatous amebic encephalitis are well recognized clinicopathological entities caused by free-living amebas. Associated arteritis and “mycotic aneurysms” with infiltration of intracranial arteries by lymphocytes, amebic trophozoites and cysts have not been previously reported. A 26-month-old girl had a 3-week history of encephalitis, characterized, initially, by vomiting and lowgrade fever. Subsequently, she developed ataxia, generalized weakness, lethargy, and esotropia. The first CSF showed 490 RBC/μl, 705 WBC/μl with 90% mononuclears. Her pupils reacted briskly to light. Moderate nuchal rigidity, nystagmus, fixed downward gaze, anisocoria, bilateral 6th nerve palsy, left arm monoparesis and left Babinski were present. CAT scan revealed slight symmetrical dilatation of anterior horns of lateral ventricles and an area of abnormal enhancement above the 3rd ventricle. She died 14 days after admission, 5 weeks after onset of symptoms. The brain showed focal necrotizing encephalopathy, involving thalami, cerebellum, brain stem, and cervical and upper thoracic spinal cord. Numerous free-living amebic trophozoites and cysts were present within a chronic granulomatous encephalitis. There were thrombosis of basilar, posterior cerebral, and vertebral arteries with profuse chronic panarteritis, fibrinoid necrosis, and mycotic aneurysms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00692213
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  • 3
    Digitale Medien
    Digitale Medien
    Acute hexachlorophene encephalopathy: Clinico-neuropathological correlation (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 93-103 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Hexachlorophene Intoxication ; Toxic Encephalopathy ; Optic Nerve Necrosis ; Cerebral Edema ; Status Spongiosus ; Electron Microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This is the first report of neuropathologic findings following oral ingestion of hexachlorophene in the human. The patient was a 7 year old boy who accidentally ingested 45 ml (approx.) of pHisoHex (hexachlorophene).Toxic reactions included nausea, vomiting, anorexia, diarrhea, decrease in visual acuity, blurred vision blindness, somnolence and disorientation. He developed cardiac arrhythmia, fever, isoelectric EEG and finally respiratory and cardiac arrest 61 h after admission. Autopsy findings showed interstitial myocarditis, pneumonitis and acute bronchiolitis. The brain was edematous. Light microscopy revealed mild diffuse vacuolization of white matter, occasional neuronal degeneration, most prominent on deepest layers of the visual cortex. Disintegration of myelin sheaths and necrosis of axon cylinders were present throughoutoptic pathways. Electron microscopy revealed large, empty extracellular and intramyelinic spaces formed by splitting and separation of the myelin lamellae. These changes are known to occur in experimental animals intoxicated with hexachlorophene, triethyltin, isonicotinic acid hydrazide and cuprizone. However, with respect to hexachlorophene, the localization of lesions to be optic pathways appears to be dependent upon an oral route of administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00710320
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  • 4
    Digitale Medien
    Digitale Medien
    Extraocular muscles: Morphogenetic study in humans light microscopy and ultrastructural features (1977)
    Springer
    Acta neuropathologica 38 (1977), S. 87-93 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Human fetal muscle ; Electron microscopy ; Motor end-plate ; Extraocular muscles
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The development of human extraocular muscles (EOM) was studied in a series of fetal specimens (12–24 weeks gestation). EOM were evaluated by enzyme histochemistry (EZ) (NADH and ATPase), by differential phase contrast microscopy (DPC) and electron microscopy (EM). In the early fetus (14 weeks), there was no clear-cut sub-division into fibre types. A uniform histochemical reaction was seen with NADH while ATPase showed light and dark myotubes. Myotubes contained large central nuclei, prominent eccentric nucleoli, abundant glycogen granules, free ribosomes, numerous mitochondria, and dense and looser bundles of myofilaments. Mesenchymal cells undergoing mitosis and fibroblasts with prominent stacks of rough endoplasmic reticulum were scattered within endomysium. Mast cells with well formed cytoplasmic granules were found as early as 18–24 weeks. The same specimens by DPC showed differentiation into at least 4 different fibre types at 12 weeks. All the intramuscular nerves at 12–16 weeks were composed of unmyelinated fibres. At 18 weeks, myelinated axons were present. Morphologically immature end-plates devoid of junctional folds were found at 12 weeks. The motor innervation of some EOM appears to be derived from more than one axon (multiple innervated fibres). At 18 weeks gestational age, differentiation into fibre types became apparent by enzyme histochemistry. These histochemical and morphological findings suggest that morphologically mature endplates are not prerequisites for differentiation into muscle fibre types.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688553
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  • 5
    Digitale Medien
    Digitale Medien
    Malignant fibrous mesothelioma (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 173-177 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Mesothelioma ; Pleura ; Metastases ; Brain ; Ultrastructure ; Asbestos
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A malignant fibrous mesothelioma in a 52 year old white man arising from the left parietal pleura associated with lupus erythematosus with metastases to brain and liver is reported. Asbestos bodies were found in digested pulmonary tissue but none in the primary or metastatic lesions. Light microscopic and ultrastructural studies suggest that this tumor contains mesothelial or endothelial cells, some of which revealed fibroblastic features while others disclosed epitheloid characteristics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687543
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  • 6
    Digitale Medien
    Digitale Medien
    Meningoencephalitis due to acanthamoeba SP (1977)
    Springer
    Acta neuropathologica 37 (1977), S. 183-191 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Acanthamoeba ; Naegleria ; Meningoencephalitis ; Granulomatous ; Free-living amebas ; Cysts ; Trophozoites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Amebic Meningoencephalitis (AM) and Primary Amebic Meningoencephalitis (PAM) are infectious diseases essentially confined to the Central Nervous System (CNS) and caused by free-living amebas of the genusAcanthamoeba (A.) andNaegleria (N.) respectively. AM due toA. sp. (Acanthamoeba castellanii andAcanthamoeba culbertsoni) have been reported in chronically ill debilitated individuals, some of them under immunosuppressive therapy, or in immunologically impaired patients without a history of recent swimming in contrast to cases due toN.sp. which usually occurs in healthy, young individuals with a recent history of swimming in man-made lakes or heated swimming pools. AM due toA.sp. is characterized by a subacute or chronic granulomatous meningoencephalitis involving mainly the midbrain, basal areas of the temporal and occipital lobes and posterior fossa structures. CNS lesions in AM are perhaps secondary and the portal of entry in humans is probably from the lower respiratory tract, genitourinary system or skin reaching the CNS by hematogenous spread. The predominant host reaction is usually composed of lymphocytes, plasma cells, monocytes and multinucleated foreign body giant cells. Necrosis is moderate and hemorrhage scant or absent. Cysts as well as trophozoites may be seen within the CNS lesions. PAM is due toNaegleria fowleri and is characterized by an hemorrhagic necrotizing meningoencephalities with an acute inflammatory response. Only trophozoites are found in lesions. The portal of entry is through the olfactory neuroepithelium. CNS tissues fixed in formalin may be used for further identification and taxonomical classification of the causative protoza using immunofluorescent antibody techniques (IFAT) and electron microscopic methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00686877
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  • 7
    Digitale Medien
    Digitale Medien
    Extraocular muscles light microscopy and ultrastructural features (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 237-253 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Strabismus ; Extraocular muscles ; Hirano bodies ; Ultrastructure ; Luse bodies ; Leptomeres
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Thirty extraocular muscles (EOM) from 20 patients were evaluated by light microscopy (LM), electron microscopy (EM), and enzyme histochemistry (EZH). Twenty-one EOM were obtained from 13 patients with strabismus, 9 EOM from 4 patients undergoing eye surgery for other reasons and from 3 autopsy cases. One μm thick sections revealed marked variation in muscle fibre shape and size and in myofibrillar structure; also noted were small, hypertrophied, whorled, and ringbinden fibres. Dense and granular material in the central portion of some fibres and sarcomere disruption in 2–3 μm sections was observed. EZH revealed the absence of the classical mosaic pattern usually found in skeletal muscles. ATPase studies were inconsistent and did not correlate with the expected reciprocal activity of NAD-H diaphorase, particularly on the large fibres. Ultrastructural features consisted of vacuoles within myofilament bundles, “smearing” of Z bands, and “nemaline rods”. Occasional myelin figures and lipid-like droplets were observed in subsarcolemmal spaces, associated with scattered clusters of glycogen granules. Abnormal mitochondria and subsarcolemmal inclusions of dense and granular material were conspicuous. “Leptomeric” profiles, “Zebra bodies”, or “striated bodies” were noted in 8 EOM's, and an Hirano body was found in 1. The intramuscular nerves contained structures resembling “Luse bodies” in 7 cases. These observations suggest that EOM from individuals with and without strabismus possess unique structural characteristics suggestive of developmental and morphological disarrangement of contractile elements. Some of these changes might play a role in the pathogenesis of strabismus and in the development of clinical symptoms. These features are significantly different from striated skeletal muscle. Therefore the criteria used in the pathological evaluation and diagnosis of skeletal muscle disorders cannot be unequivocally applied to EOM investigations. These data establish the necessity to determine histological norms, ultrastructural patterns, and develop new enzyme histochemistry criteria for the evaluation of EOM. Only then can an acceptable comparison of EOM and skeletal muscle be made.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688678
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