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  • 1
    Electronic Resource
    Electronic Resource
    Retinal S-antigen immunoreactivity in medulloblastomas (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 204-207 
    Details
    ISSN: 1432-0533
    Keywords: S-Antigen ; Monoclonal antibodies ; Cerebellar medulloblastoma ; Photoreceptor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688104
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 224-227 
    Details
    ISSN: 1432-0533
    Keywords: S-Antigen ; Monoclonal antibody ; Pineal gland ; Pineocytoma ; Pineoblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688043
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Periventricular leukomalacia: a correlation study between real-time ultrasound and autopsy findings (1985)
    Springer
    Neuroradiology 27 (1985), S. 292-300 
    Details
    ISSN: 1432-1920
    Keywords: Brain ; ultrasound ; leukomalacia ; preterm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to validate the accuracy of real-time ultrasound (US) in the diagnosis of periventricular leukomalacia (PVL). US changes of PVL were correlated with autopsy results. During a 12-month period, all premature infants of 34 weeks' gestation or less (group A) and all neonates of more than 34 weeks' gestation who presented with abnormal neurological signs (group B) were studied with an ATL mechanical sector scanner (5 and 7.5 MHz). The overall incidence of PVL was 13.3%. In group A (n=83), 13 infants had PVL and 3 died. In group B (n=36), three developed PVL and two died. Autopsy was performed in the five infants. US revealed the sequence of lesion:-the early stage with increased echogenicity in the periventricular white matter,-the late stage with area of reduced echogenicity appearing in the most echogenic zone and resulting in cystic cavitation. Autopsy confirmed PVL lesions in all five infants. The increased echogenicity corresponded to necrosis with either vascular congestion and/or secondary bleeding, the reduced echogenicity to cystic degeneration with gliosis. US scan be used for the detection of PVL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339560
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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