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  • 1
    Electronic Resource
    Electronic Resource
    Hormonal modulation of brain tumour growth: a cell culture study (1989)
    Springer
    Acta neurochirurgica 101 (1989), S. 129-133 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumours ; tissue culture ; cell proliferation ; glucocorticoid receptors ; androgen receptors ; dexamethasone and testosterone growth regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue samples derived from two neuroepithelial tumours and five meningiomas were obtained at surgery from seven patients and cultured in order to study the effect of dexamethasone (DEX) and testosterone acetate (TA) on cell proliferation. Glucocorticoid and androgen receptors (GR, AR) were determined both on tissue samples (7 cases) and on five out of the seven cell cultures obtained by tumours. GR and AR were present respectively in 5 and in 4 out of the tumour specimens assayed and in 4/5 and 2/3 of the tested cell cultures. DEX activity on cell growth was tested on six cell cultures. Four of them showed a significant growth inhibition at the highest drug concentration. On the contrary, a significant growth stimulation was observed in four out of the five cultures, where GR were present, using low hormone concentrations. Treatment with pharmacological doses of TA caused a significant cytotoxicity in all the tested cultures. Low TA concentrations inhibited cell growth in one out of the two cell cultures which contained AR, but were ineffective in cultures lacking AR. Our preliminary results suggest a possible role in growth regulation by DEX and TA in intracranial tumours, on the basis of the presence of specific hormone receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410528
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Post-traumatic malignant glioma. Report of a case (1996)
    Springer
    Neurological sciences 17 (1996), S. 283-286 
    Details
    ISSN: 1590-3478
    Keywords: Brain tumor ; Head injury ; Oligodendroglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Solo pochi dei casi riportati nella letteratura scientifica soddisfano pienamente i criteri stabiliti per accettare l'origine post-traumatica di alcune neoplasie endocraniche. Presentiamo il caso di un paziente il quale, molti anni dopo aver subito un trauma cranico commotivo nella regione parietale sinistra, ha manifestato una sintomatologia compatibile con un processo espansivo endocranico. Le neuroimmagini (TC e RM) hanno mostrato una estesa neoplasia nella regione temporo-parieto-occipitale sinistra. Una biopsia stereotassica ha evidenziato un glioma misto in continuità diretta con la cicatrice del pregresso trauma.
    Notes: Abstract Only a few cases reported in the literature fulfil the currently established criteria for accepting the traumatic origin of some intracranial tumors. A case of post-traumatic glioma is presented. Several years after sustaining a commotive left parietal trauma, our patient developed symptoms of intracranial tumor. Neuroimaging (CT and MRI) showed a large neoplasia in the left temporo-parietal-occipital region, and stereotactic biopsy revealed a mixed glioma in continuity with the scar resulting from the trauma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997787
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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