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  • 1
    Electronic Resource
    Electronic Resource
    Hormonal modulation of brain tumour growth: a cell culture study (1989)
    Springer
    Acta neurochirurgica 101 (1989), S. 129-133 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumours ; tissue culture ; cell proliferation ; glucocorticoid receptors ; androgen receptors ; dexamethasone and testosterone growth regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue samples derived from two neuroepithelial tumours and five meningiomas were obtained at surgery from seven patients and cultured in order to study the effect of dexamethasone (DEX) and testosterone acetate (TA) on cell proliferation. Glucocorticoid and androgen receptors (GR, AR) were determined both on tissue samples (7 cases) and on five out of the seven cell cultures obtained by tumours. GR and AR were present respectively in 5 and in 4 out of the tumour specimens assayed and in 4/5 and 2/3 of the tested cell cultures. DEX activity on cell growth was tested on six cell cultures. Four of them showed a significant growth inhibition at the highest drug concentration. On the contrary, a significant growth stimulation was observed in four out of the five cultures, where GR were present, using low hormone concentrations. Treatment with pharmacological doses of TA caused a significant cytotoxicity in all the tested cultures. Low TA concentrations inhibited cell growth in one out of the two cell cultures which contained AR, but were ineffective in cultures lacking AR. Our preliminary results suggest a possible role in growth regulation by DEX and TA in intracranial tumours, on the basis of the presence of specific hormone receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410528
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  • 2
    Electronic Resource
    Electronic Resource
    Bone metastasis associated with shunt-related peritoneal deposits from a pineal germinoma (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 78-83 
    Details
    ISSN: 0942-0940
    Keywords: Pineal germinoma ; extracranial metastasis ; haematogenous spread ; shunt related spread
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 15-year-old boy with a pineal germinoma is reported. The patient first underwent a ventriculoperitoneal (VP) shunt followed by a stereotactic biopsy, then, because of the rapidly deteriorating neurological status, an emergency craniotomy with subtotal removal of the tumour was performed. Two months after surgery, a left femoral metastasis and extensive peritoneal lesions became evident; they were regarded as due to haematogenous and VP shunt spread of the germinoma. At that time, extremely high serum levels of placental alkaline phosphatase were detected. The patient died 6 months after the inital diagnosis. The occurrence of extraneural metastases as well as of shunt related peritoneal deposits from primary intracranial germinoma is discussed. As far as we know this is the first reported case of a combination of haematogenous as well as VP shunt spread of a pineal germinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405704
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  • 3
    Electronic Resource
    Electronic Resource
    Modification of the Talairach Stereotactic System for CT-Compatibility: Technical Note (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 367-370 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Stereotaxy; Aalairach apparatus; CT scan; brain tumors; instrumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modification of the Talairach stereotactic system is described which is able to incorporate CT data and provides both co-ordinate calculations, directly from the CT console screen and by a fiducial reference system. The device maintains the original base plate, thus allowing its interfacing with all the accessories of the early apparatus and its direct use in the stereotactic operating room. The instrument has shown great reliability in the localisation of brain lesions and considerable flexibility in many stereotactic operations such as biopsy procedures, brachytherapy, radiosurgery and stereotactically assisted resections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050110
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  • 4
    Electronic Resource
    Electronic Resource
    Resection surgery for partial epilepsy. Relation of surgical outcome with some aspects of the epileptogenic process and surgical approach (1994)
    Springer
    Acta neurochirurgica 130 (1994), S. 101-110 
    Details
    ISSN: 0942-0940
    Keywords: Partial epilepsy ; resective surgery ; prognostic factors ; statistics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In spite of the progressive improvement of the results of resective surgery for epilepsy, the number of not significantly benefited patients remains high. An attempt was made to find out a relation between outcome and some aspects of the pathophysiological organization of the epileptogenic process and of the surgical procedure. Chi-square and logistic regression statistic analyses were utilized. The study was retrospectively performed on 138 surgically treated patients having a minimum follow-up of three years. Three classes of surgical outcome were considered: completely seizure free (including aura; 86 cases, 62.3%), significant seizure reduction (31 cases, 22.5%), and no significant improvement (21 cases, 15.2%). What follows was brought into evidence by the study. 1) On the diagnostic side, the spatial arrangement (focal, unilateral, multifocal) of both the interictal and the ictal epileptic electrocerebral activities are significantly associated with the surgical outcome. Their relative impact on outcome is related to the presence of a structural lesion: when a lesion is documented, the interictal activity has the higher value; vice versa, when no lesion is apparent, the role of the ictal activity is prevalent. However, the presence, as well as the nature of the lesion, per se, are not significantly associated with outcome. 2) On the surgical side, the extent of resection of both the structural lesion and of the epileptogenic zone are highly associated with the surgical result; the extent of lesion resection prevails on that of the epileptogenic zone. The type of surgical approach (hemispherectomy: 17 cases; temporal lobectomy: 67 cases; extratemporal resection: 54 cases) has no significant relation to the outcome. The value and the limits of the results obtained are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405509
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  • 5
    Electronic Resource
    Electronic Resource
    Interstitial brachytherapy for low-grade cerebral gliomas: Analysis of results in a series of 36 cases (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 97-105 
    Details
    ISSN: 0942-0940
    Keywords: Brachytherapy ; brain tumours ; low-grade gliomas ; stereotaxy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results obtained with interstitial brachytherapy in thirty-six low-grade cerebral gliomas (2 pilocytic astrocytomas, 23 astrocytomas and 11 oligodendrogliomas) are reported (mean follow-up: 75 months, range 37–159). All tumours were situated in locations which did not call for surgical removal as the treatment of choice. Their volume ranged from 4 to 82 cc (m=32); the Karnofsky performance status (KPS) of the treated patients lay between 0.60 and 0.90. The sources utilized (Iridium-192 in 32 cases and Iodine-125 in 4) were implanted permanently in 22 patients and temporarily in 14, using the Talairach stereotactic apparatus. The mean peripheral dose was 89.7 Gy for the permanent implants and and 42.8 Gy with a rate of 32.05 cGy/h for the temporary implants. External beam irradiation was added for tumour volumes greater than 35 cc (19 cases) on a second target volume extending 2 cm beyond the tumoural borders treated with interstitial irradiation. The survival estimates for the entire group showed a probability of 82.9% at 60 months, of 56.8% at 96, 39.4% at 120 (m.s.t.: 112 months). The quality of life in the treated patients was satisfactory, KPS never falling below a mean score of 0.70. The extent of the target volume turned out to be the most significant factor influencing survival at the multivariate analysis. Severe neurological impairment due to radionecrosis occurred in 4 patients (11%), three of them requiring surgical decompression. Target volume and radiation dose showed a direct correlation with the risk of radionecrosis at the regression analysis, the critical values being 35 cc and 100 Gy (permanent implants) or 50 Gy (42 cGy/h, temporary implants) respectively. The analysis of the results indicates that, even though many questions still remain open, brachytherapy can represent a valid alternative to surgery for tumours not suitable for surgical removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401459
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  • 6
    Electronic Resource
    Electronic Resource
    Factors of Surgical Outcome in Tumoural Epilepsy (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 819-824 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Tumoural epilepsy; lesionectomy; focus resection; factors of outcome.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Objectives. The purposes of the study were the assessment of the role of surgery in the suppression of epilepsy due to low-grade primitive cerebral tumours and the search for factors relevant to the surgical outcome.  Patients and Methods. Forty-eight patients with epilepsy due to low-grade supratentorial cerebral tumours were considered. They presented drug-resistant daily to monthly seizures since for least one year (mean 7 yrs). Twenty-four patients underwent a combined tumour and epileptogenic zone resection (“epilepsy surgery”) and 24 tumour resection alone (“lesionectomy”). The surgical outcome was evaluated two years after surgery. Several variables related to the characteristics of the epilepsy, the tumour and surgery, were considered for a possible association with the outcome. Statistical analyses were performed.  Results. Seizure freedom, including aura, was obtained in 35 patients (72.9%). Mild permanent complications occurred in 6 cases. Seizure suppression was significantly associated with complete tumour resection (post-surgical CT or MRI) and relatively low presurgical seizure frequency; it was also related, though not significantly, to small tumour size and histological grade I. The surgical outcome was only slightly better following “epilepsy surgery” than “lesionectomy”. However: i) the extent of tumour resection was not relevant regarding the “epilepsy surgery” outcome, while significantly influencing the outcome after “lesionectomy”; ii) the presurgical frequency of seizures and, to a less extent, the tumour size, had a higher influence on the outcome after “lesionectomy”.  Conclusion. Long-lasting and drug-resistant epilepsy due to cerebral tumours can be suppressed surgically in the majority of cases. The extent of tumour resection and the frequency of the seizures are the most relevant prognostic factors. Both “epilepsy surgery” and “lesionectomy” can provide good results. However, the two approaches should not be regarded as interchangeable: a choice of the approach based on the characteristics of seizures and of the tumour appears relevant to improve the surgical prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050382
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  • 7
    Electronic Resource
    Electronic Resource
    Post-traumatic malignant glioma. Report of a case (1996)
    Springer
    Neurological sciences 17 (1996), S. 283-286 
    Details
    ISSN: 1590-3478
    Keywords: Brain tumor ; Head injury ; Oligodendroglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Solo pochi dei casi riportati nella letteratura scientifica soddisfano pienamente i criteri stabiliti per accettare l'origine post-traumatica di alcune neoplasie endocraniche. Presentiamo il caso di un paziente il quale, molti anni dopo aver subito un trauma cranico commotivo nella regione parietale sinistra, ha manifestato una sintomatologia compatibile con un processo espansivo endocranico. Le neuroimmagini (TC e RM) hanno mostrato una estesa neoplasia nella regione temporo-parieto-occipitale sinistra. Una biopsia stereotassica ha evidenziato un glioma misto in continuità diretta con la cicatrice del pregresso trauma.
    Notes: Abstract Only a few cases reported in the literature fulfil the currently established criteria for accepting the traumatic origin of some intracranial tumors. A case of post-traumatic glioma is presented. Several years after sustaining a commotive left parietal trauma, our patient developed symptoms of intracranial tumor. Neuroimaging (CT and MRI) showed a large neoplasia in the left temporo-parietal-occipital region, and stereotactic biopsy revealed a mixed glioma in continuity with the scar resulting from the trauma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997787
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