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  • 1
    Electronic Resource
    Electronic Resource
    Zur Photolyse des ZinksulfidsProfessor Robert Schwarz zum 60. Geburtstage gewidmet (1947)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 255 (1947), S. 45-64 
    Details
    ISSN: 0372-7874
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird Über Versuche berichtet, die unternommen wurden, die Bedingungen zu studieren, die die Lichtempfindlichkeit des Zinksulfids beeinflussen.Es wird im einzelnen Folgendes festgestellt: 1 Die Belichtungstemperatur besitzt keinen wesentlichen Einfluß auf den Ablauf der Photolysereaktionen.2 Die Kristallstruktur ist entgegen der bisherigen Auffassung ohne wesentliche Bedeutung.3 Lichtempfindlichkeit und Korngrößenverteilung der Präparate gehen parallel, und es lassen sich aus einem Präparat durch Fraktionieren nach der Korngröße verschieden lichtempfindliche Fraktionen gewinnen. Es lassen sich weiterhin durch hydrothermale Synthese aus Zinksulfid reine Blenden herstellen, die dieselbe Lichtempfindlichkeit haben, wie hochgeglühte Präparate mit Wurtzitstruktur.Die Wirkung von Schwermetallzusätzen wird untersucht und auf Grund der von M. BODENSTEIN für die Silberhalogenide entwickelten Anschauungen diskutiert.Abschließend wird Über Versuche berichtet, die den Einfluß der Konzentrationsbedingungen bei der Fällung von reinem ZnS und von Lithopone zum Gegenstand haben.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19472550106
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of effect of photosensitizers on cytotoxicity of photodynamic therapy in human breast cancer cell cultures (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 167-176 
    Details
    ISSN: 1432-0711
    Keywords: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxy-phenylchlorin (m-THPC) (=Temoporfin®).Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture.Results: We found a dose-response for m-THPC alone ranging from 2 to 16 μg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 μg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light.Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634488
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  • 3
    Electronic Resource
    Electronic Resource
    Assessment of effect of photosensitizers on cytotoxicity of photodynamic therapy in human breast cancer cell cultures (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 167-176 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.  Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxyphenylchlorin (m-THPC) (=Temoporfin®). Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture. Results: We found a dose-response for m-THPC alone ranging from 2 to 16 µg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 µg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light. Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634488
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  • 4
    Electronic Resource
    Electronic Resource
    Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 155-159 
    Details
    ISSN: 1432-1440
    Keywords: Tumor suppressor gene ; Chromosome 18q ; Breast cancer ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inactivation of tumor suppressor genes is thought to be a critical step in tumorigenesis. TheDCC (deleted in colorectal carcinoma) gene, located on the long arm of chromosome 18, has been shown to be frequently deleted in colorectal tumors. To investigate the involvement of allelic deletions on chromosome 18q in breast cancer tumorigenesis we analyzed 28 primary breast tumors and 28 colorectal, tumors (24 carcinomas, 4 adenomas) with four different polymorphic DNA markers detecting RFLPs on chromosome 18q. In breast cancer we found loss of heterozygosity (LOH) in 4 of 27 (15%) informative cases whereas 15 of 25 (60%) colorectal tumors showed allelic deletions. In all cases of allelic loss theDCC locus or its proximal vicinity (locus SSAV1) were involved. LOH on chromosome 18q occurs both in breast and colorectal cancer, yet the frequency of these deletions in breast tumors is lower than in colorectal tumors. Moreover, in breast cancer these mutations were only detected in large and undifferentiated tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575448
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  • 5
    Electronic Resource
    Electronic Resource
    Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 155-159 
    Details
    ISSN: 1432-1440
    Keywords: Key words Tumor suppressor gene ; Chromosome 18q ; Breast cancer ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Inactivation of tumor suppressor genes is thought to be a critical step in tumorigenesis. The DCC (deleted in colorectal carcinoma) gene, located on the long arm of chromosome 18, has been shown to be frequently deleted in colorectal tumors. To investigate the involvement of allelic deletions on chromosome 18q in breast cancer tumorigenesis we analyzed 28 primary breast tumors and 28 colorectal tumors (24 carcinomas, 4 adenomas) with four different polymorphic DNA markers detecting RFLPs on chromosome 18q. In breast cancer we found loss of heterozygosity (LOH) in 4 of 27 (15%) informative cases whereas 15 of 25 (60%) colorectal tumors showed allelic deletions. In all cases of allelic loss the DCC locus or its proximal vicinity (locus SSAV1) were involved. LOH on chromosome 18q occurs both in breast and colorectal cancer, yet the frequency of these deletions in breast tumors is lower than in colorectal tumors. Moreover, in breast cancer these mutations were only detected in large and undifferentiated tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575448
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  • 6
    Electronic Resource
    Electronic Resource
    Über das Schwefelmonoxyd. 4. Mitteilung. Die Oxydation des Schwefels (1934)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 220 (1934), S. 268-272 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Oxydation von Schwefel wird unter verschiedenen Bedingungen auf die Entstehung von Schwefelmonoxyd hin untersucht.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19342200307
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesis of (R)-Sulforaphane Using [cpru(R, R)-CHIRAPHOS)]+ as Chiral AuxiliaryEnantioselective organic syntheses using chiral transition metal complexes, part 3. For part 2 see ref. [1]. (1997)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 3 (1997), S. 713-716 
    Details
    ISSN: 0947-6539
    Keywords: asymmetric synthesis ; dioxiranes ; ruthenium ; sulforaphane ; sulfoxides ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new enantioselective (80% ee) synthesis of (R)-sulforaphane and its epimer (S)-sulforaphane is described, which makes use of the pseudo-tetrahedral complex fragment [CpRu-(CHIRAPHOS)]+ as a chiral auxiliary. Reaction of the chloride complexes [CpRu(L-L)Cl] [L-L = 1,-bis(diphenylphosphino)ethane (dppe), (2S,3S)-and (2R,3R)-bis(diphenylphosphino)-butane ((S,S)- and (R, R)-CHIRAPHOS, respectively)] with phthalimidobutyl methyl sulfide gives the thioether complexes [CpRu(L-L)(MeSC4H8NPhth)]PF6. Oxygen transfer from dimethyldioxirane (DMD) produces the corresponding sulfoxide complexes in high yield and high diastereoselectivity. Cleavage of the phthaloyl group with aqueous hydrazine and subsequent reaction with thiophosgene yields the sulforaphane complexes [CpRu(L-L)(MeS(O)C4H8NCS)]PF6. Treatment of these with sodium iodide finally liberates the sulforaphane without noticeable racemization.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.19970030510
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  • 8
    Electronic Resource
    Electronic Resource
    Van der Waals model for filled rubbers with modified interfacial contacts (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 35 (1988), S. 345-362 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: It is shown how the global deformation mechanism in filler-loaded vulcanizates were modified by additional filler-to-matrix bonds. A quantitative description is given in terms of an extended van der Waals treatment including the formulation of a reduced mechanical equation of state. An interpretation of the Mullins softening is presented.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1988.070350206
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  • 9
    Electronic Resource
    Electronic Resource
    Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 711-720 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To simulate production-scale conditions of gluconic acid fermentation by Gluconobacter oxydans, different experimental setups are presented in this study. From the determination of the time constants of a production-scale reactor, it can be concluded that mixing and oxygen transfer are the rate-limiting mechanisms. This results in oxygen concentration gradients which were simulated in a one-compartment reactor in which the oxygen concentration was fluctuated by a fluctuated gassing with air and nitrogen. It could be concluded that only very long periods of absence of oxygen (ca. 180 s) results in lower specific oxygen uptake rates by Gluconobacter oxydans. From scale-down studies carried out in a two-compartment system to simulate a production-scale reactor more accurately, it could be concluded that not only the residence time in the aerated part of the system is important, but the liquid flow in between the different parts of the reactor is also an essential parameter. It could also be concluded that the microorganisms are not influenced negatively by the fluctuated oxygen concentrations with respect to their maximal oxidation capacity. The two-compartment system can also be used for optimization experiments in which the “aerated” compartment was gassed with pure oxygen. From these experiments it was concluded that also a short residence of the cells at high oxygen concentrations diminished the growth and product formation rates. These experiments show the necessity of the scale-down experiments if optimization is carried out. The two-compartment system presented in this study is a very attractive tool for reliable scale-down experiments.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260270521
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  • 10
    Electronic Resource
    Electronic Resource
    Preparation of 1-Hydroxycyclopentanecarboxylic Acid Derivatives from a Chiral Equivalent of Glycolic Acid (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 477-483 
    Details
    ISSN: 1434-193X
    Keywords: Radical reactions ; Glycolic acid ; Asymmetric synthesis ; Annulation ; Selenium ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -The stereoselective preparation of 1-hydroxycyclopentanecarboxylic acid derivatives is reported. The key reaction is either a radical cyclization or a radical annulation mediated by the transfer of a phenylseleno group. The radical precursors are easily synthesized by two consecutive enolate alkylations. Excellent stereochemical control for the quaternary C(1) stereogenic center has been achieved.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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