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  • 1
    Electronic Resource
    Electronic Resource
    Reversible posterior leukoencephalopathy after combination chemotherapy (2000)
    Springer
    Neuroradiology 42 (2000), S. 895-899 
    Details
    ISSN: 1432-1920
    Keywords: Key words Chemotherapy ; Cytarabine ; Cyclophosphamide ; Adriamycin ; Leukoencephalopathy ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, verified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340000482
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Should i.m. injections be avoided during cancer chemotherapy? (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 531-532 
    Details
    ISSN: 1432-1335
    Keywords: Intramuscular injection ; Cancer chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intravascular transit of malignant tumor cells constitutes an important step in the formation of distant metastases. The development of tumors in extravascular tissues depends upon the exit of these cells from the circulation by crossing the barriers formed by endothelium and basement membrane and their growth in the extravascular environment. Cytostatic drugs may disturb the function of these barriers and some of them, as well as antiemetic drugs, are given as i.m. injections. Thus these both mechanically and chemically induced endothelial and extravascular tissue changes might facilitate tumor cell transit to extravascular tissues. These aspects are discussed in this case report of a young female patient with a mediastinal germ cell tumor. At 4 years after complete remission induced with chemotherapy and radiotherapy she developed recurrent germ cell tumor in the form of a s.c. gluteal abscess. This gluteal region is the most common site of i.m. injections during or after cancer chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391508
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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