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  • Cell & Developmental Biology  (3)
  • Computergraphik  (2)
  • DNA repair  (2)
  • 1
    Electronic Resource
    Electronic Resource
    2D- und 3D-Parameterbilder zur Analyse der Kontrastmittelverteilung bei dynamischen CT- und MR-Untersuchungen (1998)
    Springer
    Der Radiologe 38 (1998), S. 832-840 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Kontrastmitteldynamik ; Parameterbilder ; Milz ; Mamma ; Computergraphik ; Key words Contrast medium analysis ; Parametric images ; Spleen ; Female breast ; Computer graphics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aim: For dynamic contrast medium (CM) studies, parameter images exploit specific features of the time/intensity curve (TIC) of each pixel and represent these values in a new image. Exisiting concepts of two-dimensional CM analysis are extended for three-dimensional applications using adequate computer graphic visualization. Methods: Imaging: intravenous CM injection; first-pass analysis using fast CT acquisition of a single slice; CM accumulation by 40 MR slices (6 sequences every 90 s=240 images). Software: TIC of arbitrary 2D/3D regions; parameter images: (1) temporal maximum intensity projection (TMIP) of all voxels over time, (2) temporal CM gradients (TG) based on TIC amplitude, (3) TIC slope, (4) time of TIC peak, (5) correlation coefficient to reference TIC. The calculated 3D data of CM accumulation was visualized using multiplanar reformation, MIP, surface reconstruction, volume rendering, texture mapping and animation. Results: In first-pass analyses, TMIP and TG allowed the simultaneous or separated presentation of different temporal phases of the CM bolus. Correlation images emphasized regions with similarities to given TIC patterns. Three-dimensional computer graphic techniques enabled (1) anatomical/functional mapping of original image and CM accumulation and (2) fused display of both spatial CM enhancement and color-encoded time of TIC peak in one common image. Conclusions: The quantification of presence, magnitude, and time-of-peak of CM accumulation in local image regions supports the assessment of vascularization and of ischemic or necrotic areas.
    Notes: Zusammenfassung Ziel: Bei dynamischen Kontrastmittel- (KM) Studien können spezifische Merkmale der Zeit/Intensitäts-Kurve (ZIK) eines jeden Bildpunktes verwendet und in Form von Parameterbildern dargestellt werden. Aufbauend auf bestehenden Konzepten der zweidimensionalen Analyse der KM-Dynamik soll eine dreidimensionale Erweiterung mit adäquater computergraphischer Visualisierung realisiert werden. Methode: Bildgebung: Intravenöse KM-Injektion; First-pass-Analyse mit CT bei schneller Akquisition einer einzigen Schicht; Untersuchung der längerfristigen KM-Anreicherung mit 40 MR-Schichten (6 Sequenzen alle 90 s=240 Bilder). Softwareentwicklungen: ZIK beliebiger ROIs/VOIs; Parameterbilder: 1. Maximum-Intensitäts-Projektion (TMIP) aller Pixel als Funktion über die Zeit; 2. zeitliche KM-Gradienten (TG) anhand der ZIK-Amplitude; 3. ZIK-Steigung/Gefälle; 4. Zeitpunkte der ZIK-Maxima; 5. Korrelationskoeffizienten zu Vergleichs-ZIK. Die berechneten 3D-Daten der KM-Anreicherung wurden mittels multiplanarer Reformatierung, MIP, Oberflächenrekonstruktion, Volume Rendering und Textur-Mapping visualisiert und animiert. Ergebnisse: TMIP und TG erlaubten bei First-pass-Analysen die simultane oder getrennte Präsentation unterschiedlicher Zeiträume des KM-Bolus. Die Korrelationsbilder gestatteten die Hervorhebung von Regionen, die Ähnlichkeiten zu vorgegebenen ZIK-Mustern aufwiesen. Computergraphische Techniken gestatteten 1. ein anatomisch/funktionales Mapping von Originalbild und KM-Anreicherungsverhalten sowie 2. die fusionierte Darstellung von KM-Anreicherungsbetrag und farbkodierter Zeit des KM-Maximums in einem gemeinsamen Bild. Schlußfolgerungen: Die exakte Quantifizierung von Präsenz, Grad und Ankunftszeit des Kontrastmittels in lokalen Bildregionen unterstützt die Beurteilung der Vaskularisation sowie von ischämischen bzw. nekrotischen Arealen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050431
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  • 2
    Electronic Resource
    Electronic Resource
    Multimedia presentation of radiological image data using the internet (1997)
    Springer
    Der Radiologe 37 (1997), S. 98-103 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Internet ; World-Wide-Web ; Animation ; 3D-Darstellung ; Computergraphik ; Key words Internet ; World Wide Web ; Animation ; 3D reconstruction ; Computer graphics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aim: Recent developments of the Internet (World Wide Web) allow the integration of audio, video, digital film sequences, and three-dimensional data. The applicability of these innovations for medical documentation is demonstrated. Methods: Our existing software for medical image processing and 3D reconstruction was extended to provide images, film sequences, and complex 3D models in an Internet-compatible data format. Results: The multimedia results of the image processing were integrated into Internet documents. Specialized programs are no longer necessary for visualization. The Internet software allows for user-friendly handling and interactive presentation of the 2D and 3D data. Conclusions: The Internet offers public-domain software for display of images, audio/video, and 3D data. Thus, the tools of the Internet represent an ideal basis for local hospital information systems, computer-aided medical education, and teleconferencing.
    Notes: Zusammenfassung Ziel: Neueste Entwicklungen im Umfeld des Internet ermöglichen die Integration von Audio, Video, digitalen Filmsequenzen und dreidimensionalen Daten. Die Eignung dieser aktuellen Fortschritte für den Einsatz in der medizinischen Dokumentation soll demonstriert werden. Methode: Unsere bestehende Software zur medizinischen Bildauswertung und 3D-Rekonstruktion wurde erweitert, so daß Bilder, animierte Filmsequenzen und komplexe 3D-Modelle in Datenformaten erzeugt werden können, die im Internet gebräuchlich sind. Ergebnisse: Eine direkte Einbindung der multimedialen Ergebnisse in Internetdokumente wurde ermöglicht. Zur Betrachtung der Daten sind keine komplizierten, spezialisierten Programme mehr notwendig, sondern per Internetsoftware können 2D- und 3D-Resultate bequem visualisiert werden. Schlußfolgerungen: Das Internet stellt kostenfreie bzw. kostengünstige Software zur Darstellung von Ton, Bildern, Filmsequenzen und 3D-Modellen zur Verfügung. Somit bieten sich die Techniken des Internet in idealer Weise als Basis für lokale Krankenhaus-Informationssysteme, computergestützte medizinische Ausbildung und Telekonferenzen an.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050183
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  • 3
    Electronic Resource
    Electronic Resource
    Histone shuttling by poly ADP-ribosylation (1994)
    Springer
    Molecular and cellular biochemistry 138 (1994), S. 53-59 
    Details
    ISSN: 1573-4919
    Keywords: poly(ADP-ribose)polymerase ; poly(ADP-ribose) glycohydrolase ; DNA repair ; chromatin ; nucleosomal unfolding ; NAD+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The enzymes poly(ADP-ribose)polymerase and poly(ADP-ribose) glycohydrolase may cooperate to drive a histone shuttle mechanism in chromatin. The mechanism is triggered by binding of the N-terminal zinc-finger domain of the polymerase to DNA strand breaks, which activates the catalytic activities residing in the C-terminal domain. The polymerase converts into a protein carrying multiple ADP-ribose polymers which displace histones from DNA by specifically targeting the histone tails responsible for DNA condensation. As a result, the domains surrounding DNA strand breaks become accessible to other proteins. Poly(ADP0ribose) glycohydrolase attacks ADP-ribose polymers in a specific order and thereby releases histones for reassociation with DNA. Increasing evidence from different model systems suggests that histone shuttling participates in DNA repairin vivo as a catalyst for nucleosomal unfolding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00928443
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation of 8-methoxypsoralen accessible DNA domains from chromatin of intact cells (1990)
    Springer
    Cell biology and toxicology 6 (1990), S. 35-45 
    Details
    ISSN: 1573-6822
    Keywords: Chromatin organization ; DNA repair ; hepatocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: The chromatin organization of living mammalian cells was probed using 8-methoxypsoralen (MOP). In intact cells, MOP intercalates into DNA domains which are also preferentially accessible to micrococcal nuclease. After UV365 nm irradiation of MOP-treated cells, this chemical forms bifunctional adducts crosslinking the two strands of DNA. Following extraction of cellular DNA, heat denaturation and renaturation at low temperature, the fraction of crosslinked DNA is obtained following enzymatic hydrolysis of unhybridized, non-crosslinked DNA ny nuclease S1 treatment. An application of this procedure in the isolation of 8-methoxypsoralen-accessible DNA domains during DNA excision repair is shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00135025
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  • 5
    Electronic Resource
    Electronic Resource
    Selected nuclear matrix proteins are targets for poly(ADP-ribose)-binding (1998)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 70 (1998), S. 596-603 
    Details
    ISSN: 0730-2312
    Keywords: poly(ADP-ribose) ; PARP ; nuclear matrix ; noncovalent interactions ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Recent evidence suggests that poly(ADP-ribose) may take part in DNA strand break signalling due to its ability to interact with and affect the function of specific target proteins. Using a poly(ADP-ribose) blot assay, we have found that several nuclear matrix proteins from human and murine cells bind ADP-ribose polymers with high affinity. The binding was observed regardless of the procedure used to isolate nuclear matrices, and it proved resistant to high salt concentrations. In murine lymphoma LY-cell cultures, the spontaneous appearance of radiosensitive LY-S sublines was associated with a loss of poly(ADP-ribose)-binding of several nuclear matrix proteins. Because of the importance of the nuclear matrix in DNA processing reactions, the targeting of matrix proteins could be an important aspect of DNA damage signalling via the poly ADP-ribosylation system. J. Cell. Biochem. 70:596-603. © 1998 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 6
    Electronic Resource
    Electronic Resource
    On the vas spirale in the adult pig (1926)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 33 (1926), S. 121-135 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1090330208
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  • 7
    Electronic Resource
    Electronic Resource
    On the epithelial relations of the stapes in the pig (1923)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 26 (1923), S. 121-128 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1090260206
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