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  • 1
    Electronic Resource
    Electronic Resource
    Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin (1999)
    Springer
    Diabetologia 42 (1999), S. 1171-1174 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Skeletal muscle ; adipose tissue ; intramyocellular lipids ; lipolysis ; insulin resistance.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Both patients with Type II (non-insulin-dependent) diabetes mellitus and normoglycaemic, insulin resistant subjects were shown to have an increased lipid content in skeletal muscle, which correlates negatively with insulin sensitivity. Recently, it was shown that during a hyperinsulinaemic euglycaemic clamp interstitial glycerol was reduced not only in adipose tissue but also in skeletal muscle. To assess whether lipolysis of muscular lipids is also regulated by low physiological concentrations of insulin, we used the microdialysis technique in combination with a 3-step hyperinsulinaemic glucose clamp. Methods. Nineteen lean, healthy subjects (12 m/7 f) underwent a glucose clamp with various doses of insulin (GC I = 0.1, GC II = 0.25 and GC III = 1.0mU · kg–1· min–1). Two double lumen microdialysis catheters each were inserted in the paraumbilical subcutaneous adipose tissue and in skeletal muscle (tibialis anterior) to measure interstitial glycerol concentration (index of lipolysis) and ethanol outflow (index of tissue flow). Results. During the different steps of the glucose clamp, glycerol in adipose tissue was reduced to 81 ± 7 % (GC I), 55 ± 8 % (GC II) and 25 ± 5 % (GC III), respectively, of basal. In contrast, glycerol in skeletal muscle declined to 73 ± 5 % (GC I) and to 57 ± 6 % (GC II) but was not further reduced at GC III. Tissue flow was higher in the skeletal muscle and remained unchanged in both compartments throughout the experiment. Conclusion/interpretation. This study confirms the presence of glycerol release in skeletal muscle. Lipolysis in skeletal muscle and adipose tissue are suppressed similarly by minute and physiological increases in insulin but differently by supraphysiological increases. Inadequate suppression of intramuscular lipolysis resulting in increased availability of non-esterified fatty acids, could represent a potential mechanism involved in the pathogenesis of impaired glucose disposal, i. e. insulin resistance, in muscle. [Diabetologia (1999) 42: 1171–1174]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051288
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  • 2
    Electronic Resource
    Electronic Resource
    Alltagskompetenz: Ein Konstrukt auf der Suche nach einer Identität (1998)
    Springer
    Zeitschrift für Gerontologie + Geriatrie 31 (1998), S. 243-249 
    Details
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Altern – Alltag – Alltagskompetenz ; Key words Aging – everyday life – everyday competence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The goal of this paper is to contribute to conceptual issues associated with the construct of everyday competence. After the description of reasons for the increased attention which everyday competence has found within gerontology, the first section of this work serves to shed light on six research traditions with relevance for everyday competence: (1) Research on everyday cognitive processes, (2) ADL/IADL research, (3) leisure time research, (4) coping research, (5) time budget research, and (6) ecological gerontology research. In the second section, two influential models of everyday competence, namely those of Margret Baltes and Sherry Willis, are discussed. Finally, an integrative conception of everyday competence, which is aimed to combine aspects of the six research traditions with elements of the two models of everyday competence, is suggested.
    Notes: Zusammenfassung Die vorliegende Arbeit will einen konzeptuellen Beitrag zum Konstrukt der Alltagskompetenz leisten. Nach der einleitenden Erörterung von Gründen für die verstärkte Beachtung von Alltagskompetenz in der Gerontologie werden in einem ersten Teil sechs Forschungsströmungen mit Relevanz für Alltagskompetenz skizziert: 1. alltagsnahe kognitive Alternsforschung, 2. ADL/IADL-Forschung, 3. Freizeitforschung, 4. Bewältigungsforschung und 6. ökologisch-gerontologische Forschung. In einem zweiten Teil werden zwei einflußreiche Modelle von Alltagskompetenz, jene von Margret Baltes und Sherry Willis, dargestellt und diskutiert. In einem dritten Teil wird eine integrative Konzeption von Alltagskompetenz vorgestellt, welche Aspekte der sechs Forschungsströmungen mit wesentlichen Elementen der beiden Alltagskompetenzmodelle verzahnt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003910050040
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  • 3
    Electronic Resource
    Electronic Resource
    Development of the blood vessels of the mammary gland in the rabbit (1915)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 18 (1915), S. 515-524 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1000180306
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    Paper (German National Licenses)
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