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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 262 (1978), S. 37-44 
    ISSN: 1432-069X
    Keywords: Atopic dermatitis ; Cell-mediated immunity ; T-lymphocytes ; Concanavalin A ; Neurodermitis atopica ; Zellvermittelte Immunität ; T-Lymphozyten ; Concanavalin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Patienten mit Neurodermitis atopica leichten Schweregrades konnte im Rahmen einer kontrollierten Studie mit Hilfe von “matched pairs” eine gegenüber gesunden Kontrollpersonen signifikant (α=0,005) herabgesetzte in vitro 3H-Thymidin-Einbaurate in kultivierte Lymphozyten des peripheren Blutes, nach Stimulation mit dem T-Zellenmitogen Concanavalin A (Con A), festgestellt werden. Anhand von zehn differenten Konzentrationen von Con A wurden die Dosis-Wirkungsbeziehungen innerhalb der Paare bestimmt. Während höhere Con A-Konzentrationen in den Lymphozytenkulturen zu optimalen 3H-Thymidin-Einbauraten in neusynthetisierte DNS führten, waren die Unterschiede zwischen Neurodermitikern und Kontrollpersonen eindeutiger bei niedrigeren, suboptimalen Con A-Konzentrationen. Die spontane 3H-Thymidin-Einbaurate in kultivierte Lymphozyten ohne Con A-Stimulation (spontane DNS-Synthese) war bei Neurodermitikern im Vergleich zu Kontrollpersonen erhöht. Die Befunde weisen auf eine beeinträchtigte T-Zellenfunktion bei Neurodermitikern hin.
    Notes: Summary The Concanavalin A (Con A) stimulation response of peripheral lymphocytes in vitro was found to be decreased statistically significant (α=0.005) in patients with light atopic dermatitis, Strictly matched pairs were examined. Using ten graded concentrations of Con A, dose-response relations of the pairs were demonstrated, differences were more evident at lower suboptimal concentrations. Background DNA-synthesis of the patients was elevated.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0509
    Keywords: Liver, neoplasms ; Sonography ; Angiography ; Computed tomography ; Oily contrast media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the characteristics of combined hepatocellular and cholangiocarcinoma of the liver by imaging techniques, six patients (five male and one female), aged 46–60 years, with proved combined tumors were selected for this study from the review of 500 resected specimens of liver tumors. Images obtained from sonography, computed tomography (CT), angiography, and CT after intraarterial injection of iodized oil (iodized-oil CT) were retrospectively reviewed and correlated with the appearance of pathologic specimens. Sonographic findings were round or ovoid hypoechoic masses with central hyperechoic area (target appearance) in all patients. On CT scans, tumors were relatively well-defined low- and/or iso-attenuation masses in all patients. Angiography showed hypovascular masses in five patients. In one patient, the tumor appeared as a hypovascular mass with a central hypervascular area. On iodized-oil CT scans, all patients showed partial retention of iodized oil in tumors. Echogenicity in tumors at sonography or attenuation in tumors at CT could not be correlated with histologic difference in tumors at pathologic specimens. However, the hypervascular area at angiography and the compact retention areas of iodized oil at iodized-oil CT corresponded to portions of hepatocellular carcinoma within the combined tumor. On the basis of our results, imaging features, including target appearance at sonography, hypovascular mass with central hypervascular portions at angiography, and partial retention of iodized oil in tumors at iodized-oil CT, might be helpful in making accurate diagnosis of these rare tumors.
    Type of Medium: Electronic Resource
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