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  • Cellular Antibody-Formation  (1)
  • HB-Antigen  (1)
  • Immune complexes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 157 (1972), S. 87-94 
    ISSN: 1433-8580
    Keywords: Cellular Antibody-Formation ; Parabiosis ; Plaque-Technique ; Regulation of the Immune Response ; Celluläre Antikörperbildung ; Parabiose ; Immunregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Untersuchungen sollten zeigen, inwieweit bei Parabionten die Immunantwort gegenseitig beeinflußt werden kann. — NMRI-Mäuse wurden zu unterschiedlichen Zeitpunkten mit Hammelerythrocyten (HE) sensibilisiert und parabiontisch vereinigt. Durch Auszählen Antikörper-bildender Milzzellen wurde die Stärke der Immunantwort bestimmt, wobei die Plaque-Technik angewandt wurde. Durch Sensibilisieren eines einzigen Partners vor der Parabiose sollte gezeigt werden, ob einzelne Antikörper-bildende Zellen oder HE durch die Anastomose übertreten. Die Ergebnisse zeigen eine gegenseitige Beeinflussung der Immunantwort. Da einzelne Antikörper-bildende Zellen oder HE nicht übertreten, ist dieser Effekt allein zirkulierenden Antikörpern zuzuschreiben. Sie führen zu einer Hemmung der Immunantwort insbesondere bei Tieren, die kurz vor der Parabiose sensibilisiert worden sind. Die Ergebnisse bestätigen das Vorliegen eines Rückkoppelungsmechanismus und beweisen darüber hinaus, daß die Unterdrückung durch direktes Einwirken auf die Antikörper-bildenden Zellen erfolgt.
    Notes: Summary This work was designed to show whether antibodies can influence the immune responseafter sensitization. — NMRI-mice were sensitized with sheep red blood cells (SRBC) and joined by parabiosis. After different intervals the immune response was examined by detection of single antibody-forming cells using the plaque-technique. For demonstration of a possible transfer of SRBC or antibodyproducing cells only one parabiont was sensitized. The results show a mutual influence of the immune response of both parabionts. Because there is no transfer of SRBC or antibody-producing cells through the communication the influence is due to passing antibodies. Those antibodies inhibit the immune response more when animals are sensitized few days before parabiosis. The suppression of the antibody-formation in animals sensitized before parabiosis is an indication for a direct interaction of antibodies with cells producing them.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 131 (1979), S. 43-48 
    ISSN: 1432-1076
    Keywords: Immunopathogenesis ; Infectious diseases ; Immune complexes ; Gammaglobulin injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immune complexes (ICs) participate in the pathogenesis of various diseases and can be shown in 18% of all hospitalized patients (excluding those with infectious diseases) by means of a sensitive method such as the Raji-cell radioimmune assay. However, before this test can be applied to quantify disease activity in renal, connective tissue and neoplastic diseases, it must be recognized that febrile infections of the upper respiratory tract also induce ICs in 86% of all patients. The immune complexes containing microbial antigens can be reduced or removed by a single injection of human immunoglobulin. This is a simple method to distinguish between the immune complexes of different specifities. The resulting removal of some immune complexes may be the explanation for the claimed therapeutic effect of gammaglobulin injection in normogammaglobulinemic patients.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 927-928 
    ISSN: 1432-1440
    Keywords: HB-Antigen ; Hepatitis ; Polyarthritis ; HB-Antigen ; hepatitis ; polyarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 27 patients suffering from acute hepatitis serum and synovial-fluid were tested for HB-Ag. It was detected in the serum in 19 cases, in the synovial fluid in 2 cases, but never in both serum and synovial-fluid. HB-Ag was not found in 6 patients. Polyarthritis was seen in 10 cases; 5 of them carried HB-Ag in the serum, 2 in the synovial-fluid. A hepatitis B however, was also suspected in the 3 cases with polyarthritis lacking HB-Ag. The results suggest that virus B may persist in joints too and that polyarthritis associated with acute hepatitis is coupled to an infection with virus B.
    Notes: Zusammenfassung Bei 27 Patienten mit akuter Hepatitis wurden Synovialis und Serum auf das HB-Ag untersucht. Es fand sich 19mal im Serum, 2mal in der Synovialis, aber niemals in beiden. Bei 6 Patienten wurde es nicht gefunden. Eine Polyarthritis bestand in 10 Fällen, von denen 5 das HB-Ag im Serum und 2 in der Synovialis hatten. Doch auch bei den übrigen 3 Fällen mit Polyarthritis ohne HB-Ag war eine Hepatitis B anzunehmen. Die Ergebnisse zeigen, daß das Hepatitis-B-Virus auch in Gelenken persistieren kann und eine Polyarthritis bei akuter Hepatitis an eine Infektion mit Virus-B gebunden ist.
    Type of Medium: Electronic Resource
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