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  • 1
    Electronic Resource
    Electronic Resource
    Sex hormone binding and peritumoural oedema in meningiomas: Is there a correlation? (1992)
    Springer
    Acta neurochirurgica 115 (1992), S. 98-102 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral oedema ; meningioma ; progesterone receptor ; steroid receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Steroid receptor binding activity was evaluated in specimens of 28 human cerebral meningiomas using a dextran coated charcoal (DCC) assay. Oestrogen receptor (ER) binding activity at significant levels (〉 10 fmol/mg protein) could be detected only in three postmenopausal females (11% positive cases) at low levels. Positive progesterone receptor (PR) binding was detected in eighteen of the twenty-eight analysed meningioma tissues (64% positive cases). A significantly higher level of PR in male than in female patients could be demonstrated. The degree of peritumoural oedema could be evaluated from CT scans. There was no significant correlation between lack and amount of peritumoural oedema and quantity of cytosolic PR binding activity. Therefore we conclude, that peritumoural oedema is related to other factors and a possible role of PR activity in development of peritumoural oedema and growth control of meningiomas could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406365
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical and pathophysiological significance of severe neurotrauma in polytraumatized patients (1998)
    Springer
    Langenbeck's archives of surgery 383 (1998), S. 214-219 
    Details
    ISSN: 1435-2451
    Keywords: Key words Polytrauma ; Multiple trauma ; Head injury ; Secondary brain injury ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Introduction: Traumatic brain injury (TBI) is present in up to two-thirds of multiply injured patients. The degree of TBI influenced the mortality and morbidity of multiple trauma significantly. Results: Important prognostic predictors are: injury severity score (ISS); Glasgow coma score [(GCS), motor score]; pupil size and reactivity; coma grade and duration; age; morphological primary brain lesion; and pathophysiological changes leading to secondary brain damage. The time course of brain edema, raised intracranial pressure and, especially, pathophysiology of disturbed cerebral blood flow and metabolism characterizes early and late periods of ischemic vulnerability. Conclusion: These should be taken into consideration when planning operative procedures in multiple-trauma patients. Avoidance of secondary ischemic brain damage by reducing the number of systemic insults (hypovolemia, hypotension, hypoxia) will improve prognosis of critically ill polytraumatized patients with head injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050121
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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