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Regulatory properties of neuronal cdc2-like kinase (1995)

Qi, Zhong ; Tang, Damu ; Matsuura, Isao ; [et al.]

Springer

Molecular and cellular biochemistry 149-150 (1995), S. 35-39

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ISSN: 1573-4919

Keywords: neuronal cdc2-like kinase ; cdk5 ; regulatory subunit ; neurofilament proteins ; tau ; Alzheimer disease

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview. The activity of nclk appears to be governed by highly complex regulatory mechanisms including protein-protien interaction, protein phosphorylation and isoforms. The histone H1 kinase activity of nclk is absolutely dependent of the interaction between the 25 kDa subunit and the catalytic subunit, cdk5. In addition, nclk interacts with other cellular proteins to form macromolecular complexes. The kinase activity of nclk is inhibitedin vitro by the phosphorylation reactions of a weel-like protein tyrosine kinase and a protein serine/threonine kinase from bovine thymus. Northern blot analysis has revealed the existence of two populations of p35 mRNA of 2 and 4 kb. A novel cDNA encoding a p35 homologous protein has been obtained from a human hippocampus library.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01076561

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Gravity-Driven reactive coating flow down an inclined plane (1994)

Qi, Quan ; Johnson, Robert E.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 40 (1994), S. 2-10

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: The coating flow of a reactive fluid on an inclined plane is studied. The fluid viscosity steadily increases due to a sustained cross-linking reaction. Using well-known long wave approximations and a simple kinetic relation, we find that the linear stability of a uniform coating is affected not only by the inclination angle but also by the reaction order. In the weakly nonlinear limit, a generalized Kuramoto-Sivashinsky (K-S) equation is derived. Two interesting cases are identified in the limit of creeping flow. One is when surface tension is moderate and a generalized Burger's equation results, and the other is when the surface tension is large and the traditional K-S equation is recovered when the inclination angle is greater than 90°. The solution in this case represents a shock-like traveling wave down the incline and it appears to be unique for reacting coating flows.

Additional Material: 6 Ill.