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  • Chemistry  (27)
  • Chemiluminescence  (3)
  • Gene expression  (3)
  • Estrogen  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Identification of the estrogen sensitive marker in human endometrial carcinoma RL95-2 cells
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 101 (1994), S. 167-171 
    Details
    ISSN: 0303-7207
    Keywords: Endometrium ; Estrogen ; Lactoferrin ; Oncogene ; RL95-2 cell ; c-fos ; c-myc
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(94)90231-3
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 104 (1994), S. 173-181 
    Details
    ISSN: 0303-7207
    Keywords: Estrogen ; Estrogen responsive element ; Gene expression ; Hepatocyte growth factor (HGF) ; Mouse ovary
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(94)90120-1
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  • 3
    Electronic Resource
    Electronic Resource
    Room-temperature luminescence optosensing based on immobilized metal chelates: application to iodide determination
    Amsterdam : Elsevier
    Analytica Chimica Acta 255 (1991), S. 245-251 
    Details
    ISSN: 0003-2670
    Keywords: Chemiluminescence ; Immobilized metal chelates ; Iodide ; Optosensing
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0003-2670(91)80052-U
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chemiluminescence determination of vitamin B"1"2 by a flow-injection method
    Amsterdam : Elsevier
    Analytica Chimica Acta 243 (1991), S. 127-130 
    Details
    ISSN: 0003-2670
    Keywords: Chemiluminescence ; Flow system ; Vitamin B"1"2
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0003-2670(00)82550-7
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chemiluminescence determination of vitamin B"1"2 by a flow-injection method
    Amsterdam : Elsevier
    Analytica Chimica Acta 243 (1991), S. 121-125 
    Details
    ISSN: 0003-2670
    Keywords: Chemiluminescence ; Flow system ; Vitamin B"1"2
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)82550-7
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  • 6
    Electronic Resource
    Electronic Resource
    Induction of cardiac angiotensin I-converting enzyme with dietary NaCl-loading in genetically hypertensive and normotensive rats (1995)
    Springer
    Journal of molecular medicine 73 (1995), S. 243-248 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin I-converting enzyme ; Gene expression ; Sodium chloride ; Heart ; Inbred rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently shown that the angiotensin I converting enzyme (ACE) gene is linked to NaCl-loaded blood pressure in the stroke-prone spontaneously hypertensive rat (SHRSP), and that high-NaCl loading selectively stimulates ACE in the aorta of SHRSP but not in normotensive Wistar-Kyoto (WKY) rats. We therefore investigated the relationship between cardiac ACE and the development of hypertension and left ventricular hypertrophy in response to normal- and high-NaCl diet in these rats. ACE mRNA and ACE activity were measured in left ventricular tissue after completion of hemodynamic characterization of the animals. While SHRSP rats increased blood pressure (P〈0.0001) and heart rate (P〈0.005) in response to high NaCl, blood pressure remained unchanged in WKY. Similarly, relative left ventricular weight increased only in SHRSP after high NaCl (P〈0.002). A significant two- to threefold increase of cardiac ACE mRNA and fourfold stimulation of ACE enzyme activity in response to high NaCl was found in both WKY and SHRSP rats (P〈0.005). The induction of ACE gene expression was significantly more pronounced in SHRSP compared to WKY (P〈0.02), whereas no significant strain differences in left ventricular ACE activity were found after either normal- or high-NaCl diet. Thus, arterial blood pressure and left ventricular weight remained unchanged in the WKY rats despite the activation of left ventricular ACE activity after high-NaCl exposure. These results demonstrate that left ventricular ACE activity is equally upregulated in response to high-NaCl in the normotensive and hypertensive strain, independently from the development of hypertension. We conclude that the pretranslational induction of left ventricular ACE with high-NaCl loading may be important both for the regulation of cardiac angiotensins and kinins and for local therapeutic ACE inhibition in the heart during high-salt status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189924
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  • 7
    Electronic Resource
    Electronic Resource
    UAS MAG1, a yeast cis-acting element that regulates the expression of MAG1, is located within the protein coding region of DDI1 (1997)
    Springer
    Molecular genetics and genomics 255 (1997), S. 533-542 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsSaccharomyces cerevisiae ; DNA damage induction ; Gene expression ; cis-acting element ; Transcriptional regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract MAG1 and DDI1 are two divergently transcribed DNA damage-inducible genes from Saccharomyces cerevisiae. Previous studies have shown that MAG1 induction requires an upstream activating site (UAS) located between nucleotides −376 and −330. Here we show that a 24-bp oligonucleotide from within the UAS MAG1 region forms a sequence-specific DNA-protein complex with partially purified proteins from S. cerevisiae. Point mutations introduced into the 24-bp oligonucleotide inhibited the formation of the DNA-protein complex and decreased the level of induction of MAG1-lacZ. By determining the transcription and translation start points of both MAG1 and DDI1, an interesting, indeed unprecedented feature of genome organization in eukaryotes was revealed: UAS MAG1 actually lies within the protein-coding region of DDI1. Although tightly linked to each other, and co-induced upon treatment with DNA-damaging agents, DDI1 does not share the UAS MAG1 required for DNA damage induction of MAG1. Furthermore, MAG1 and DDI1 respond differently in the presence of the protein synthesis inhibitor cycloheximide, suggesting that these two genes are regulated by different mechanisms in the absence of de novo protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050526
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  • 8
    Electronic Resource
    Electronic Resource
    The characterization of the metabolites of ranolazine in man by liquid chromatography mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1418-1430 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The metabolism of ranolazine (RS-43285) or (+)N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]-1-piperazine acetamide dihydrochloride was investigated in man using plasma samples obtained from four different clinical studies. The metabolite profiles following single and multiple doses of 342 mg instant release (IR) ranolazine, following multiple doses of 1000 mg sustained release (SR) ranolazine and following dosing with both ranolazine (IR) and a potentially co-administered drug, diltiazem, were compared. Metabolism of ranolazine in man was shown by LC/MS analysis to be extensive with up to seven primary routes of metabolism identified. N-dealkylation by hydrolysis at the piperazine ring produced three metabolites whilst O-demethylation and O-dearylation at the methoxyphenoxy moiety produced a further two compounds. Additionally, hydrolysis of the amide group formed one other species. Oxygenation at various points in the molecule produced a further four metabolites. Direct conjugation of ranolazine with glucuronic acid and with an uncharacterized adduct were also identified as a route of elimination. Ten other biotransformation products were formed as a result of multiple metabolic steps. Conjugation was also associated with the desmethyl metabolite (glucuronide and unidentified conjugates) of hydroxylated ranolazine. In a previous publication (Journal of Chromatography, 1995, accepted for publication) semi-quantitative analyses of pooled plasma from the study where ranolazine was dosed at 1000 mg twice daily showed that of the twelve metabolites studied only four accounted for AUC's in excess of 10% of the ranolazine AUC.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290091419
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for the presence of disulfide bridges in opioid receptors essential for ligand binding. Possible role in receptor activation (1989)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 2 (1989), S. 44-48 
    Details
    ISSN: 0952-3499
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The mobility of purified μ opioid binding protein in SDS-polyacrylamide gek electrophoresis is sensitive to the presence of reducing agents. In the presence of increasing concentrations of DTT the apparent molecular weight increases in a stepwise fashion from 53 kDa to 65 kDa. This reduction in mobility is attributed to the successive breakage of disulfide bridges, resulting in an increasingly asymmetric molecule. Treatment of cell membranes from various brain areas with reducing agents, such as DTT, produced a concentration-dependent inhibition of opioid binding. Sensitivity to DTT inhibition varied between receptor types, μ 〉 δ ≫ κ. For μ receptors, agonist binding was considerably more sensitive to DTT than antagonist binding. Inhibition by DTT is readily reversible and is unaffected by Na+ and/or Mg2+ ions. Reversibility may be partially prevented by the inclusion of a low concentration of a reducing reagent such as glutathione which does not inhibit binding but blocks reformation of disulfide bonds. Scatchard analysis of saturation data shows that DTT causes a pronounced decrease in binding affinity with little effect on receptor number. It is suggested that disulfide bonds are essential for ligand binding and that cleavage of one or more of these bonds may play a role in opioid receptor activation by agonists.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmr.300020107
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  • 10
    Electronic Resource
    Electronic Resource
    Polymer-Impregnated mortars I. Effect of polymer state on mechanical behavior (1977)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 17 (1977), S. 325-334 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Mortar specimens were impregnated with methyl methacrylate, n-butyl acrylate, styrene, and crosslinking agents in various combinations. After polymerization of the monomers in situ, studies of mechanical properties such as Young's modulus and compressive strength were made. In one experiment, various ccpolymers of methyl methacrylate and n-butyl acrylate were prepared and tested as a function of temperature. Excellent reinforcement was obtained with any combination of monomers as long as the resulting polymer was at a temperature below its glass transition temperature. This suggests that the modulus of the reinforcing polymer is crucial, glassy behavior being required. The addition of crosslinking agents such as TMPTMA increased the high temperature strength, however.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760170511
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