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  • 1
    Electronic Resource
    Electronic Resource
    Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines (1992)
    Springer
    Acta neurochirurgica 117 (1992), S. 38-43 
    Details
    ISSN: 0942-0940
    Keywords: Dorsal root entry zone lesion ; neuropeptides ; catecholamines ; CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of dorsal root entry zone lesions (DREZLs) on cerebrospinal fluid (CSF) and plasma concentrations of neuropeptides, catecholamines, and cyclic nucleotides were studied in 9 patients with intractable chronic pain. Contents of β-endorphin-like-material in CSF decreased in all patients 12–17 days following DREZLs during which complete to good pain relief was achieved. Contents of β-endorphin-like-material in CSF increased again about one month after DREZLs in two and remained unchanged in one of three patients tested, who complained of partial reappearance of pain. Contents of β-endorphin-like-materials in plasma showed no significant changes after DREZLs. Substance P, noradrenaline, adrenaline, and cyclic nucleotide levels in both CSF and plasma were variable among the subjects and did not change significantly following the operations. Thus, the results suggest that production of β-endorphin-like-material in the central nervous system is decreased by DREZL, though the increase in its turn-over might not be neglected. The mechanisms of the decrease in contents of β-endorphin-like-material in CSF after DREZLs were discussed in terms of our current knowledge of pain and pain inhibitory systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400633
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Typical molecular ion peak analysis of morphinone- and codeinone-glutathione adducts with sodium iodide using fast atom bombardment mass spectrometry (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 24 (1989), S. 286-288 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210240418
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Alterations in Superoxide Dismutase Isozymes by Methylmercury (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 11 (1997), S. 635-643 
    Details
    ISSN: 0268-2605
    Keywords: methylmercury ; superoxide dismutase ; mouse ; oxidative stress ; gene expression ; enzyme inhibition ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A study of alterations in two mammalian superoxide dismutases (SODs), Cu,Zn-SOD and Mn-SOD, caused by methylmercury has been reviewed. Mechanisms for the isozyme-selective decrease in MnSOD activity by the organometallic compound observed in vivo have been extensively examined by experiments with purified enzyme preparations. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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