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  • Chemistry  (2)
  • Invasiveness  (1)
  • Kearns-Sayre-syndrome  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Comparative study of histopathological alterations during intestinal infection of mice with pathogenic and non-pathogenic strains ofYersinia enterocolitica serotype O:8 (1993)
    Springer
    Virchows Archiv 423 (1993), S. 97-103 
    Details
    ISSN: 1432-2307
    Keywords: Yersinia enterocolitica ; Peyer's patches ; Ultrastructure ; M-cell ; Invasiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Yersinia enterocolitica is an invasive pathogen capable of causing a wide spectrum of gastrointestinal diseases in man. While there is a considerable body of data on the invasiveness ofY. enterocolitica in vitro, little is known about the events in vivo leading to the translocation of the bacteria from the intestinal lumen into the ileal tissue. There is no detailed ultrastructural information describing the course of infection of pathogenicY. enterocolitica in comparison with an avirulent strain. We compared a virulent plasmid-bearing strain and an isogenic avirulent plasmid-free derivative strain ofY. enterocolitica serotype O∶8 at the ultrastructural level, in the established model of murine yersiniosis. At 12 h postinoculation we found no indications of an active invasion of the intestinal epithelium, although microcolonies of the pathogenic strain were detectable closely under the follicle-associated epithelium of the Peyer's patches. The plasmid-bearing strain ofY. enterocolitica affected the gut-associated lymphoid tissue which was destroyed 36 h post-infection. Unlike the pathogenic strain ofY. enterocolitica, the nonpathogenic plasmid-free strain caused no detectable morphological alterations in the ileal tissue by this time. Morphological evidence is provided thatYersinia does not invade the ileal epithelium in an active manner, as has been observed in vitro, but appears to be transported across the epithelial barrier by M-cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606583
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 679-681 
    Details
    ISSN: 1432-0533
    Keywords: Myopathy ; Kearns-Sayre-syndrome ; Cytochrome c oxidase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334681
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Oxidative Kupplung CH-acider Verbindungen mit p-Phenylendiaminen. VIII [1]. Synthese von 5H-Benzo[a]phenothiazin-5-onen aus Naphth[2,1-d]1,3-oxathiol-2-onen (1981)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 323 (1981), S. 785-792 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Oxidative Coupling of CH-acid Compounds with p-Phenylenediamines. VIII. Synthesis of 5H-Benzo[a]phenothiazin-5-ones from Naphth[2,1-d]1,3-oxathiol-2-onesReaction of 5-hydroxynaphth[2,1-d]1,3-oxathiol-2-ones with N,N-diethyl-quinone-1,4-diimine leads to 5H-benzo[a]phenothiazin-5-ones 1-21. The same dyes are available by use of p-substituted nitrosobenzenes in acetic acid, or in methanol in the presence of oxygen acceptors. The mechanisms of dye formation are discussed.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19813230510
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  • 4
    Electronic Resource
    Electronic Resource
    Oxidative Kupplung CH-acider Verbindungen mit p-Phenylendiaminen. VII [1]. Synthese und oxidative Kupplung von 5-Hydroxy-naphth[2,1-d]1,3-oxathiol-2-onen (1981)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 323 (1981), S. 776-784 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Oxidative Coupling of CH-acid Compounds with p-Phenylenediamines. VII. Synthesis and Oxidative Coupling of 5-Hydroxy-naphth[2,1-d] 1,3-oxathiol-2-ones5-Hydroxy-naphth[2,1-d]1,3-oxathiol-2-ones with different substituents 1-21 were synthesized using the following procedures: Condensation of substituted naphthoquinones-1,4 with thiourea (A); electrophilic substitution of 5-hydroxy-naphth[2,1-d]1,3-oxathiol-2-one (B); Fries-reaction of 5-acyloxy- and 5-N-phenylcarbamoyloxy-naphth[2,1-d]1,3-oxathiol-2-ones (C). Oxidative coupling of the compounds with N,N-diethyl-quinone-1,4-diimine yielded thiazine dyes.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19813230509
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    Paper (German National Licenses)
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