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  • 1
    Electronic Resource
    Electronic Resource
    Cyclic AMP-dependent protein kinase does not phosphorylate cyclic GMP-dependent protein kinase in vitro
    Amsterdam : Elsevier
    FEBS Letters 151 (1983), S. 71-75 
    Details
    ISSN: 0014-5793
    Keywords: Autophosphorylation ; Heat-stable inhibitor protein ; cAMP-dependent protein kinase ; cGMP-dependent protein kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(83)80345-7
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  • 2
    Electronic Resource
    Electronic Resource
    Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes (1983)
    Springer
    Pflügers Archiv 398 (1983), S. 147-154 
    Details
    ISSN: 1432-2013
    Keywords: Adrenaline ; cAMP-dependent protein kinase ; Slow inward calcium current ; Inotropy ; K outward current ; Transient inward current
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclic adenosine 3′,5′-monophosphate (cAMP) or the free catalytic subunit (C) of the cAMP-dependent protein kinase were pressure injected into single guinea pig ventricular cells. The following results were obtained: 1. Injection of cAMP prolonged the action potential and shifted the action potential plateau to a more positive level. Under voltage clamp, cAMP injection increased the amplitude of the slow inward calcium current (I si). 2. Injection of C permanently prolonged the action potential and enhanced the amplitude ofI si by a factor of 2–4, depending on the amount of injected C. In the current-voltage relations the potential of maximumI si and the apparent current reversal did not change. 3. After maximum prolongation of the action potential due to repeated injections of C, even high concentrations of adrenaline did not further change the configuration of the action potential. 4. In many experiments transient depolarizations appeared after the injection. Correspondingly, under voltage clamp transient inward currents occurred. 5. C injection increased both the time-dependent and time-independent potassium outward current. 6. In response to injection of the catalytic subunit, the isotonic contraction was larger in amplitude and relaxation was faster. It is concluded that the cAMP-dependent protein kinase increases the slow inward calcium current in the heart, presumably by phosphorylation of some membrane proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581064
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  • 3
    Electronic Resource
    Electronic Resource
    Relaxation of skinned coronary arteries depends on the relative concentrations of Ca2+, calmodulin and active cAMP-dependent protein kinase (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 70-76 
    Details
    ISSN: 1432-2013
    Keywords: Skinned coronary arteries ; Smooth muscle ; Regulation of contractile tone ; cAMP-dependent protein kinase ; cAMP-dependent modulation of contractile tone ; Calmodulin ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Maximally contracted detergent skinned coronary smooth muscle fibres are relaxed by lowering the concentration of free Ca2+. The extent and rate of relaxation depends on the concentration of free Ca2+ and calmodulin (CaM) suggesting that it is the Ca2+. CaM complex which is responsible for maintaining tension. At a fixed concentration of Ca2+ and CaM further relaxation can be achieved by addition of the catalytic subunit of the cAMP-dependent protein kinase (cAMP-kinase). The extent as well as the relaxation rate depend on the concentration of cAMP-kinase (0.01–0.5 μM) and both are antagonized by high concentrations of Ca2+ and CaM. The Ca2+-requirement for obtaining half maximal concentration is shifted from 1.1 μM to 6.3 μM Ca2+ in the presence of 0.5 μM cAMP-kinase. These data indicate that the response of the contractile apparatus to a change in the free [Ca2+] can be modulated by cAMP-kinase at the level of the contractile proteins. It is further suggested that the tone of coronary smooth muscle is determined by the relative and not by the absolute concentrations of Ca2+, CaM and cAMP-kinase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591100
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  • 4
    Electronic Resource
    Electronic Resource
    Cyclic GMP-dependent protein kinase relaxes skinned fibers from guinea pig taemia coli but not from chicken gizzard (1986)
    Springer
    Pflügers Archiv 407 (1986), S. 87-91 
    Details
    ISSN: 1432-2013
    Keywords: cGMP ; cGMP-dependent protein kinase ; Cyclie nucleotides in skinned smooth muscle ; Skinned guinea pig taenia coli ; Skinned chicken gizzard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cGMP and cGMP-dependent protein kinase (cG-PK) on contraction and relaxation was studied in skinned smooth muscle fibers from guinea pig taenia coli and chicken gizzard. At a fixed [Ca2+] relaxation was significantly enhanced by activated cG-PK in fibers from guinea pig taenia coli, but not in those from chicken gizzard. The Ca2+-requirement for half maximal tension maintenance was shifted to the right. Relaxation was associated with a decline in phosphorylated myosin light chain-2 from 34% to 25%. Similarly to relaxation activated cG-PK inhibited tension development only in fibers from taenia coli. These results suggest that mammalian and chicken smooth muscle fibers respond differently to cG-PK.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580726
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  • 5
    Electronic Resource
    Electronic Resource
    cGMP and cAMP inhibit tension development in skinned coronary arteries (1984)
    Springer
    Pflügers Archiv 401 (1984), S. 277-280 
    Details
    ISSN: 1432-2013
    Keywords: cGMP ; cAMP ; Skinned coronary arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of physiological concentrations of cGMP and cAMP on tension development in skinned coronary arteries (Triton X-100) were studied. cGMP inhibited tension elicited at intermediate Ca2+ concentrations at pH 7.0 but not at more acidic or alkaline pH values. cAMP, on the other hand, decreased submaximal tension development independent of pH (from pH 6.5 to pH 7.2). Neither nucleotide affected tension development at maximally activating Ca2+ concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582596
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  • 6
    Electronic Resource
    Electronic Resource
    Untersuchung der Verbindungseigenschaften an laserstrahlgefügten Brillengestellen (1998)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 281-291 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Investigation of Laser Beam Joining Properties for Eye Glass Frame ManufactureIn the production of high-grade eye glass frames of stainless steel increase the application of laserbeam joining technology in comparison to conventional processes. In a study it should be established, with which process (brazing or welding), the practical requirements of eye glass frames could be realized. Profiles made of Cr-Ni-steel which are used in practice due to their corrosion resistance, were joined with laser beam. To characterize the properties of joints, the quality of specimens were tested concerning mechanical properties (hardness, strength, ductility) and structural constitution. In relation to the requirement of good ductility of the joints, it was possible to proof the advantages of the welded samples.
    Notes: Bei der Fertigung von hochwertigen Brillengestellen aus nichtrostenden Stählen gewinnt der Einsatz der Laserstrahlfügeverfahren im Vergleich zu konventionellen Verfahren zunehmend an Bedeutung. Im Rahmen einer Studie sollte festgestellt werden, welches der beiden Verfahren Löten und Schweißen die in der Praxis gestellten Anforderungen an Brillengestelle besser erfüllt. Hierzu wurden Profile aus Cr-Ni-Stahl, wie sie in der Praxis wegen ihrer besonderen Langzeitstabilität gegenüber Korrosion eingesetzt werden, mittels Laserstrahl gefügt. Zur Charakterisierung der metallurgischen Eigenschaften der Fügeverbindungen wurden die Qualitätsmerkmale der Proben hinsichtlich mechanischer Eigenschaften (Härte, Festigkeit und Verformbarkeit) sowie die Gefügeausbildung untersucht. Im Hinblick auf die geforderte gute Verformbarkeit der Verbindungen konnte für die geschweißten Proben ein Vorteil gegenüber dem Laserstrahllöten nachgewiesen werden.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19980290607
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  • 7
    Electronic Resource
    Electronic Resource
    Enhanced chemiluminescent immunoassay for aldosterone (1990)
    New York : Wiley-Blackwell
    Journal of Bioluminescence and Chemiluminescence 5 (1990), S. 49-52 
    Details
    ISSN: 0884-3996
    Keywords: Aldosterone ; enhanced chemiluminescence ; immunoassay ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A solid phase immunoassay for aldosterone using enhanced chemiluminescent detection has been developed. Monoclonal antibodies against aldosterone were used for the immune reaction and compared with polyclonal antibodies. Uniform Protein A coated polystyrene tubes were used as solid phase for the monoclonal antibody and second (anti-rabbit) antibody coated tubes for the polyclonal antibody. Horseradish peroxidase was covalently linked to aldosterone as enzyme label. Optimum conditions were established for the generation and measurement of the luminescent reactions using luminol, p-iodophenol as enhancer and hydrogen peroxide.The advantages of this assay are the high sensitivity with a detection limit of 100fg/tube, the prolonged luminescence signal with a simplification of the measurement (simpler detectors, external start pipetting) and the short measure time with the possibility of repeated measurement. The coefficients of variation were 4.2%-7.3% in the concentration range 140-1180 pmol/l. The assay showed a significant correlation (r = 0.91) with the ELISA.The aldosterone concentrations in plasma and saliva of patients with Conn's syndrome were significantly increased, and in patients with Addison's disease were found near the detection limit.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bio.1170050110
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  • 8
    Electronic Resource
    Electronic Resource
    Zerkleinerungstechnik (1976)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 48 (1976), S. 993-999 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330481114
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  • 9
    Electronic Resource
    Electronic Resource
    Darstellung und Struktur des N,N′ -DithioformylanilinsProfessor Josef Goubeau zum 85. Geburtstage am 31. März 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 534 (1986), S. 7-12 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Structure of N,N′-DithioformylanilineN,N′-dithioformylaniline was prepared by treating N,N′-dichlormethylaniline [1] with silicon disulfide [2]. The compound is characterized by the results of a X-ray structural analysis (RW = 0.030) as well as its nmr and vibration spectra. N,N′-dithioformylaniline crystallizes in the orthorhombic space group P21212 with a = 537.0(2); b = 745.7(3); c = 1111.5(4) pm; V = 445.1(3) · 106 pm3. The molecule consists of two planar parts; the angle between the plane of the aromatic ring and the plane of the N,N′-dithioformylamino group was determined to 87.7°.
    Notes: N,N′-Dithioformylanilin konnte durch Umsetzung von N,N′-Dichlormethylanilin [1] mit Siliciumdisulfid [2] dargestellt werden. Die Verbindung ist durch die Ergebnisse einer Röntgenstrukturanalyse (RW = 0,030) sowie ihre NMR- und Schwingungsspektren charakterisiert. N,N′-Dithioformylanilin kristallisiert orthorhombisch in der Raumgruppe P21212 mit Z = 2 und a = 537,0(2); b = 745,7(3); c = 1111,5(4) pm; V = 445,1(3) · 106 pm3. Das Molekül weist zwei planare Bauteile auf; der Winkel zwischen der Ebene des Aromaten und der durch die N,N′-Dithioformylaminogruppe gelegten Ebene wurde zu 87,7° bestimmt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865340302
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  • 10
    Electronic Resource
    Electronic Resource
    Die Kristall- und MolekülStruktur des N,N′-DiformylanilinsProfessor Josef Goubeau zum 85. Geburtstage am 31. März 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 534 (1986), S. 13-18 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Crystal and Molecular Structure of N,N′-DiformylanilineN,N′-diformylaniline crystallizes in the monoclinic space group P21/n with Z = 8 and a = 856.1(2), b = 1277.6(3), c = 1306.1(3) pm, β 92.29(2)°, V = 1427.4(5) · 106 pm3. As shown by X-ray structure determination (2642 symmetry independent reflections, RW = 0.034) the molecule exists in two enantiomeric forms. The molecular structure can be described by two planes; the angle between the plane of the aromatic ring and the plane of the N,N′-diformylamino group is 70.1 resp. 108.3°. The results are compared with those obtained for other derivats.
    Notes: N,N′-Diformylanilin kristallisiert monoklin in der Raumgruppe P21/n mit Z = 8 und a = 856,1(2); b = 1277,6(3); c = 1306,1(3) pm; β = 92,29(2)°; V = 1427,4(5) · 106 pm3. Nach den Ergebnissen der Röntgenstrukturanalyse (2642 symmetrieunabhängige Reflexe; RW = 0,034) existiert das Molekül in zwei enatiomeren Formen. Die Molekülstruktur kann durch zwei Ebenen beschrieben werden; der Winkel zwischen der Ebene des Aromaten und der durch die N,N′-Diformylaminogruppe gelegten Ebene beträgt 70,1 bzw. 108,3°. Die Ergebnisse werden mit denen anderer Derivate verglichen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865340303
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