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  • 1
    Digitale Medien
    Digitale Medien
    Lack of a lipoprotein-induced insulin resistance in hepatoma cells in culture (1986)
    Springer
    Diabetologia 29 (1986), S. 457-461 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin resistance ; lipoproteins ; liver ; insulin binding ; insulin action ; hepatoma cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A lipoprotein-induced resistance to the action of insulin has been postulated. To test this hypothesis, cultured ratderived hepatoma cells, designated FAO, and human-derived hepatoma cells, designated HEP-G2, were incubated for 20 h in the presence or absence of lipoproteins; specific 125I-insulin receptor binding and labeled glucose incorporation into glycogen were then measured. Very low density lipoproteins (d 〈 1.006 g/ml) in physiologic (0.5 mg/ml) or pathophysiologic (5 mg/ml) concentrations did not modify insulin receptor binding of FAO or HEP-G2 cells. This was true for very low density lipoproteins derived from normal human, diabetic human, and streptozotocin-diabetic rat plasma. Low density lipoproteins (d=,.019–1.063g/ml) isolated from normal human plasma similarly failed to modify insulin receptor binding. Concerning insulin action, the different very low density lipoprotein preparations did not modulate either basal or insulin-stimulated glucose incorporation into glycogen of the cells. Thus, very low density lipoproteins and low density lipoproteins did not induce insulin resistance in cultured hepatoma cells either at the insulin receptor level or at the post-receptor level.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00506539
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  • 2
    Digitale Medien
    Digitale Medien
    Reduced insulin binding to hepatic plasma membranes in D-galactosamine-treated rats (1979)
    Springer
    Diabetologia 17 (1979), S. 101-109 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Galactosamine hepatitis ; hyperinsulinaemia ; insulin resistance ; liver plasma membranes ; insulin binding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Six to 12 h after IP injection of 400 mg/kg of D-galactosamine in rats a 5-fold increase in plasma insulin was observed. In addition, impaired glucose assimilation was present after an IV load in spite of unchanged fasting glucose levels. In streptozotocin-diabetic rats (100 mg/kg IV) plasma insulin remained diminished 12 h after induction of D-galactosamine hepatitis. Under identical conditions of preparation and incubation, the liver plasma membranes of D-galactosamine-treated rats, in both normal and diabetic states, bound only 40–60% as much insulin per mg of membrane protein as those of the control rats. Scatchard analysis suggested that this was due to a decrease in the number of receptor sites in the membranes of the D-galactosamine-injected rats. No difference in the insulin degrading capacity and in insulin-receptor dissociation of the plasma membranes between control and D-galactosaminetreated groups was found. These data suggest that a reduction in the number of hepatic insulin receptors in galactosamine hepatitis can lead to insulin resistance and hyperinsulinaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01222210
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  • 3
    Digitale Medien
    Digitale Medien
    Zur Kenntnis des Lycopins. XI. Mitteilung über Pflanzenfarbstoffe (1929)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 12 (1929), S. 285-291 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19290120130
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  • 4
    Digitale Medien
    Digitale Medien
    Über einen Apparat zur Bestimmung der Dampfspannungsisothermen des Gels der Kieselsäure (1912)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 75 (1912), S. 189-197 
    Details
    ISSN: 0863-1778
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19120750118
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  • 5
    Digitale Medien
    Digitale Medien
    Über neue Filter (1918)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 103 (1918), S. 119-128 
    Details
    ISSN: 0863-1786
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19181030107
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  • 6
    Digitale Medien
    Digitale Medien
    Über die Spaltung der Doppelbindung im Neoergosterol (1959)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 42 (1959), S. 1790-1793 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: By a careful sidechain cleavage of neoergosteryl acetate, 3,β-hydroxy-ar, B-bisnorcholanaldehyde could be isolated as its crystalline dimethyl acetal (Va). Acetylation and bromination afforded 3β-acetoxy-20-bromo-ar, B-bisnorcholanaldehyde(VI), which was converted to the 2,4-dinitrophenylhydrazone of 3β-acetoxy-ar, B-Δ17:20-bisnorcholenaldehyde (VII).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19590420607
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