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  • 1
    Electronic Resource
    Electronic Resource
    Rare association of herpes simplex virus IgM-specific antibodies and Guillain-Barré syndrome successfully treated with plasma exchange and immunosuppression (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 468-474 
    Details
    ISSN: 1432-1440
    Keywords: Guillain-Barré syndrome (GBS) ; Herpes simplex virus (HSV)-IgM antibodies ; Immunohistology ; Plasma exchange ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV) has been associated with various neurological disorders. In contrast, HSV infection is very rarely found in acute polyneuroradiculitis. In this report, a patient is described with a severe course of Guillain-Barré syndrome (GBS). HSV IgM-specific antibodies and a rise of complement-fixation antibodies were detected. During the acute phase of neurologic syndrome, a nerve biopsy showed myelin damage and IgM deposits on the inner layer of the perineurium. Plasma exchange, in combination with immunosuppression, was successfully applied as a treatment in the relapsing course of GBS. Finally, after recovery, HSV-specific IgM antibodies disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731495
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological aspects of chromosome spindle fibres inMesostoma: “microtubular fir-tree” structures and microtubule association with kinetochores and chromatin (1991)
    Springer
    Protoplasma 160 (1991), S. 39-48 
    Details
    ISSN: 1615-6102
    Keywords: Chromosome movements ; Kinetochore microtubules ; Microtubule-chromatin lateral associations ; Crossbridges ; Meiosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Bipolarly oriented bivalents in spermatocytes of the turbellarianMesostoma ehrenbergii, displaying fast oscillatory movements in metaphase, were studied with the electron microscope. Kinetochores and chromosome fibres were reconstructed using serial sections cut perpendicular to the spindle axis. Only a small proportion of kinetochore microtubules (kMT) is continuous between the kinetochore and the centrosome. kMTs intermingle with non-kinetochore microtubules (non-kMTs), partly inclined with regard to the kMTs, thus forming a chromosome fibre MT lattice. This resembles the “microtubular fir-tree” structures (MTFT) described by Bajer and Molè-Bajer inHaemanthus endosperm mitosis. A minimal function of the MTFT may be the anchorage of kMTs in the polar region. Regarding the association of MTs with the chromosome, three types of attachment can be discriminated: (1) “normal” insertion of kMT plus ends in the kinetochore, (2) penetration of kinetochores and deep insertion in the chromatin, and (3) lateral attachment with kinetochore and chromatin. Lateral association of MTs seems to be mediated by filamentous crossbridges. The observations are discussed in connection with possible behaviour of kMTs during kinetochore movement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539955
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    Paper (German National Licenses)
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