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  • 1
    Electronic Resource
    Electronic Resource
    Isolierung und nähere Charakterisierung eines neuen Haptoglobins: Hp-Marburg (1965)
    Springer
    Annals of hematology 12 (1965), S. 65-77 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A hereditary haptoglobin variant (HpMb) was isolated from the serum of one of the carriers. The immunoelectrophoretically pure Hp showed, just as the serum, an atypical starch gel aspect. In immunological studies of the Hp-Hb complexes, HpMb showed only a partial identity to normal Hp's of groups Hp 1–1, Hp 2–1, and Hp 2–2. The particular antigen properties were demonstrable in all starch gel bands. The occurence of a special antigen determinant of the HpMb-Hb complex is probably connected with an atypia of the Hb binding capacity of HpMb.
    Notes: Zusammenfassung Eine erbliche Haptoglobin-Variante (HpMb) wurde aus dem Serum eines der Merkmalsträger isoliert. Das immunoelektrophoretisch reine Hp zeigte wie das Serum ein atypisches Stärkegelbild. Bei immunologischer Untersuchung der Hp-Hb-Komplexe zeigte HpMb nur eine Teilidentität mit normalen Hp der Gruppen Hp 1–1, Hp 2–1 und Hp 2–2. Die besonderen Antigeneigenschaften waren in sämtlichen Stärkegelbanden nachweisbar. Das Auftreten einer besonderen Antigendeterminante des HpMb-Hb-Komplexes hängt wahrscheinlich mit einer Atypie der Hb-Bindungsfähigkeit des HpMb zusammen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01631544
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  • 2
    Electronic Resource
    Electronic Resource
    Rare association of herpes simplex virus IgM-specific antibodies and Guillain-Barré syndrome successfully treated with plasma exchange and immunosuppression (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 468-474 
    Details
    ISSN: 1432-1440
    Keywords: Guillain-Barré syndrome (GBS) ; Herpes simplex virus (HSV)-IgM antibodies ; Immunohistology ; Plasma exchange ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV) has been associated with various neurological disorders. In contrast, HSV infection is very rarely found in acute polyneuroradiculitis. In this report, a patient is described with a severe course of Guillain-Barré syndrome (GBS). HSV IgM-specific antibodies and a rise of complement-fixation antibodies were detected. During the acute phase of neurologic syndrome, a nerve biopsy showed myelin damage and IgM deposits on the inner layer of the perineurium. Plasma exchange, in combination with immunosuppression, was successfully applied as a treatment in the relapsing course of GBS. Finally, after recovery, HSV-specific IgM antibodies disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731495
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  • 3
    Electronic Resource
    Electronic Resource
    Inherited Immunologically Atypical Haptoglobin (1962)
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 1091-1092 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the course of investigations with a modified agar-gel diffusion technique5'6 for the demonstration of the three Hp types, one serum was encountered which did not give the usual reaction of identity. As shown in Fig. 1, serum B. Wi. showed a distinct spur formation when tested next to normal sera ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1941091a0
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  • 4
    Electronic Resource
    Electronic Resource
    Physics of Strengthening Mechanisms in Crystalline Solids (1971)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Materials Research 1 (1971), S. 313-346 
    Details
    ISSN: 0084-6600
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ms.01.080171.001525
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of "bamboo" grain boundaries on the maximum electromigration-induced stress in microelectronic interconnect lines (1998)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 83 (1998), S. 3595-3599 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A model which describes the steady-state mechanical stresses resulting from electromigration in microelectronic interconnect lines is presented. This model is valid when sidewall and grain boundary interface diffusion are the dominant transport paths, and accounts for the two-dimensional microstructure present in such lines. By applying the model to simulated line microstructures, we find that bamboo grain boundaries may substantially increase the maximum electromigration stress. Furthermore, microstructural simulations on bounded interconnect segments show that variations in grain size may lead to a large scatter in the maximum stress, particularly as line length decreases. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.366576
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  • 6
    Electronic Resource
    Electronic Resource
    Electromigration failure by shape change of voids in bamboo lines (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 1563-1571 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The behavior of electromigration-induced voids in narrow, unpassivated aluminum interconnects is examined, using scanning electron microscopy. Some electromigration tests were interrupted several times in order to observe void nucleation, void growth, and finally the failure of the conductor line. It is found that voids which opened the line have a specific asymmetric shape with respect to the electron flow direction. Besides void nucleation and void growth, void shape changes can consume a major part of the lifetime of the conductor line. A first attempt to model these processes on the basis of diffusion along the void surface shows that voids with a noncircular initial shape tend to produce the fatal asymmetry due to electron wind effects, with the anisotropy of surface energy possibly playing only a minor role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357734
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  • 7
    Electronic Resource
    Electronic Resource
    Role of dislocation blocking in limiting strain relaxation in heteroepitaxial films (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 7280-7287 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The residual strain following relaxation in a variety of Si1−xGex heteroepitaxial films grown on (001) Si wafers has been compared with the values of residual strain predicted by the theory based on the incremental movements of isolated threading dislocation segments. It is found that for very thin films (40–500 nm) the measured residual strains after relaxation are significantly higher than the values predicted by this theory. For thicker films, the residual strains are very close to the predicted values. The effect of the interactions of parallel dislocations on the residual strain are investigated using the model developed by Willis, Jain, and Bullough [Philos. Mag. A 62, 115 (1990)] for a two-dimensional array of dislocations. It is found that the experimental data cannot be explained by this model since it predicts even lower values of residual strain than the model based on isolated threading segments. The residual strains are also compared with predictions based on Freund's treatment of the blocking of a moving threading segment by an orthogonal misfit dislocation present in its path [J. Appl. Phys. 68, 2073 (1990)]. It is found that Freund's blocking criterion gives a very good account of the residual strain in Si1−xGex films. Blocking of threading dislocations by other misfit dislocations appears to play an important role in the late stage of strain relaxation in these structures and thus may limit the possibility of obtaining fully relaxed films with low threading dislocation densities. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.358013
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  • 8
    Electronic Resource
    Electronic Resource
    Surface-energy-driven intermixing and its effect on the measurement of interface stress (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 2816-2820 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We show that the technique of extracting interface stresses in multilayers using a force balance between layer stresses and substrate forces is extremely sensitive to small amounts of intermixing. Intermixing of as little as one half of a monolayer can produce apparent interface stresses of −2 N/m unless changes in the unstrained lattice parameter are accounted for. Diffusion and intermixing driven by large surface energy differences has been observed in several systems with large positive heats of mixing and limited bulk solid solubility, and is consistent with recently reported lattice parameter measurements in Ag/Ni multilayers. We also present in situ stress measurements in the Ag/Ni system that are consistent with this surface-energy-driven intermixing. We conclude that the reported imbalance between substrate and layer stress forces in Ag/Ni is probably not due to negative interface stresses but is more consistent with the effects of surface-energy-driven intermixing. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372261
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  • 9
    Electronic Resource
    Electronic Resource
    A physically based model of electromigration and stress-induced void formation in microelectronic interconnects (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 1932-1944 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this article, a model of electromigration and stress-induced void formation in microelectronic interconnects is presented. This model solves the equations governing atomic diffusion and stress evolution in two dimensions, and can therefore account for the complex grain structures present in typical metal lines. A combined analytical and numerical solution scheme is developed to calculate the atomic fluxes and the evolution of mechanical stress, while avoiding the difficulties associated with finite element based approaches. Once a void has formed, growth is modeled by calculating the flux of atoms away from the void site. By combining models of atomic diffusion, stress evolution, void nucleation, and void growth, the complete void formation process can be simulated. To demonstrate this approach, void growth is calculated in interconnects where electromigration and thermal stress-induced damage have been experimentally observed. The results confirm that the model can quantitatively simulate void formation in realistic grain structures. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370990
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of coherency stresses on the hardness of epitaxial Fe(001)/Pt(001) multilayers (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 2969-2971 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of coherency stresses on the hardness of epitaxial, sputter-deposited Fe(001)/Pt(001) multilayers was investigated. Coherency stresses were over 2 GPa for films with a bilayer period, Λ, of 44 A(ring) and relaxed by more than a factor of 10 for films with Λ=76 and 121 A(ring). Since the hardness of these films was constant at approximately 9 GPa over this range of Λ, we conclude that the contribution of coherency stresses to the enhanced hardness is small for this system. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.114246
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