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  • Chronic lymphocytic leukemia  (1)
  • Elterliche Reaktion nach SID  (1)
  • Key words Mannitol  (1)
  • 1
    Electronic Resource
    Electronic Resource
    „Ich habe mein Kind getötet”Erfahrungen mit schweren Depressionen bei Müttern nach Plötzlichem Kindstod aus psychiatrischer und rechtsmedizinischer Sicht* (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 53-58 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Plötzlicher Kindstod (SID) ; Elterliche Reaktion nach SID ; Tötung ; Key words Sudden infant death (SID) ; Reaction by parents after SID ; Violence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Grief and depressive syndrome belong to normal reaction by parents after a sudden infant death (SID). In the following we report on two cases from the point of view of psychiatry and forensic medicine in which, subsequent to SID, mothers reacted with extremly grave depression and occused themselves of having killed the child. Furthermore, some recommendiations are given for the care of parents affected.
    Notes: Zusammenfassung Trauer und depressive Syndrome gehören zu den normalen Reaktionen von Eltern nach einem Plötzlichen Kindestod („sudden infant death”, SID). Wir berichten im folgenden aus psychiatrischer und rechtsmedizinischer Sicht über 2 Fälle, in denen die Mütter nach SID mit außergewöhnlich schweren Depressionen reagierten und sich selbst vorwarfen, sie hätten ihr Kind getötet. Abschließend werden einige Empfehlungen für die Betreuung betroffener Eltern mitgeteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050238
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of advanced chronic lymphocytic leukemia by fludarabine (1991)
    Springer
    Annals of hematology 63 (1991), S. 1-4 
    Details
    ISSN: 1432-0584
    Keywords: Chronic lymphocytic leukemia ; Fludarabine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a clinical phase-II study fludarabine phosphate was given to 20 patients with advanced chronic lymphocytic leukemia who had failed on prior conventional therapy. Fludarabine was administered at a dose of 25 mg/m2/d for 5 days. Treatment cycles were repeated every 4 weeks until maximal response, followed by two cycles for consolidation. Four of the 20 patients achieved complete remission and seven patients partial remission, resulting in an overall response rate of 55% (11/20). Fludarabine therapy was well tolerated, with mild myelosuppression and secondary infections comprising the predominant side effects. These data warrant further confirmation and a randomized comparison of fludarabine with established regimens, which is currently underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01714952
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Slow elimination of mannitol from human cerebrospinal fluid (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 271-274 
    Details
    ISSN: 1432-1041
    Keywords: Key words Mannitol ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The rise of intracranial pressure above the pre-treatment level (rebound phenomenon) is considered, in part, a consequence of osmotherapeutics penetrating into the intracranial compartments. Methods: The kinetics of mannitol in the ventricular CSF were studied in 10 patients with cerebrovascular stroke after a single i.v. infusion of 37.5 g over 15 min. Results: Maximum mannitol CSF concentrations (mean = 51.1 mg · l−1) were reached 2–12 h after termination of the infusion. Mean t1/2CSF (18.3 h) by far exceeded t1/2S (3.71 h). AUCCSF/AUCS, as a measure of mannitol CSF penetration, ranged from 0.037 to 0.390. Conclusion: The slow elimination of mannitol from CSF implies a high risk of accumulation in the central nervous compartments after repeated dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050375
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    Paper (German National Licenses)
    Fulltext
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