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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 77 (1988), S. 202-205 
    ISSN: 1432-0533
    Keywords: Pick's disease ; Olfactory bulb ; Pick body distribution ; Light and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The olfactory bulbs and stalks were examined in a case of Pick's disease that showed numerous and widespread Pick bodies in the brain. Typical argyrophilic inclusions (Pick bodies) were found not only in many cells of the anterior olfactory nucleus but also in some mitral cells and tufted cells. In addition, neuronal loss and astrocytosis were evident. No neurofibrillary change or senile plaque were detected anywhere in these structures. Electron microscopy disclosed that there was no ultrastructural difference between Pick bodies in the olfactory bulb and those in the cerebral cortex or hippocampus. These data indicate that in Pick's disease mitral cells and tufted cells, as well as anterior olfactory nucleus cells, are affected by degeneration specific to Pick's disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Juvenile Parkinson's disease ; Classical Parkinson's disease ; Clinico-pathological comparison ; Lewy body distribution ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A clinico-pathological case report on a case of juvenile Parkinson's disease (JPD) with widespread Lewy bodies (LBs) in the brain is presented with comparative morphological studies on two demented cases of “classical” Parkinson's disease (CPD) with disease onset at an older age. The clinical and histological pictures of this JPD case were typical of Parkinson's disease, excepting numerous Lewy bodies in the cerebrum. There were no neurofibrillary change nor senile plaques throughout the CNS. The distribution and histochemical and ultrastructural characters of the histological lesions (i.e., LBs) in the JPD and the two CPD cases were investigated and compared. The comparison showed no qualitative but only quantitative differences between the two types of Parkinson's disease. The present study also revealed that in CPD cases significant numbers of LBs could be present in the cerebral cortex, amygdaloid and claustrum. These lesions can be in part responsible for dementia in CPD.
    Type of Medium: Electronic Resource
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