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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 258 (1996), S. 181-192 
    ISSN: 1432-0711
    Keywords: Key words: Ectopic pregnancy ; hCG disappearance ; Follow-up ; Persistent trophoblast ; Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In order to study the disappearance of human chorionic gonadotropin (hCG) in serum after surgery for ectopic pregnancy and to facilitate the postoperative follow-up of hCG decline serial hCG serum concentrations were analysed in 189 women with an uneventful postoperative course and in 4 patients with persistent trophoblast. A double logarithmic transformation of hCG concentrations resulted in a linear relationship of the individual hormonal decline versus the postoperative time (r2=0.990). The decrease of hCG levels was independent from the type of surgery or gestational age. The calculated half life of hCG steadily increased with rising time interval after surgery. A nomogram of hCG decrease was constructed using the regression lines of the individual sequential hormone concentrations. The nomogram enabled the detection of active residual trophoblast within one week after surgery before serious complications occur. Our scheme requires only three hCG tests to be performed before surgery, and on day 2 and 7.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Key words Lyme arthritis ; Diagnosis ; Clinical score
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnosis of Lyme arthritis (LA) in children and adolescents may be difficult due to non-specific clinical manifestations and unreliable serological tests for antibodies to Borrelia burgdorferi. In a national prospective study, 186 children with arthritis were examined in whom the attending physicians had considered the diagnosis of LA. Ultimately, LA was confirmed in 87 patients and these were compared with the remaining 99 children in whom arthritis was attributable to other causes. In comparison to patients with other causes of arthritis, patients with LA had a higher frequency of episodic arthritis and initial knee joint arthritis, reported tick bites more frequently, were older, had a lower frequency of initial arthralgias, and there were fewer large joints involved. A score was developed in a group of these patients and tested in a second group. It enabled patients with LA to be distinguished from those with other causes of arthritis: within a range from 12 to −7 points, a score of 2.5 or less excluded LA whereas 6 or more points were highly indicative of LA. If only those children with a score result between 2.5 and 6 had been tested for antibodies to B. burgdorferi, the number of tests would have been reduced by 63%. Conclusion Careful analysis of clinical presentation and use of a clinical score may help in distinguishing LA from other causes of arthritis and thus reduce unnecessary and expensive testing and uninterpretable test results.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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