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  • 1
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Lungenrundherde ; Amyloidose ; Bronchialcarcinom ; Computertomographie ; Lungenbiopsie ; Key words Lung nodule ; Amyloidosis ; Bronchial carcinoma ; Computed tomography ; Lung biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report a rare case of pulmonary nodular amyloidosis featuring all typical morphologic alterations associated with this disease; multiple amyloidomas, calcification and cavernous transformation were present. Definite diagnosis was established histologically with CT-guided biopsy. The different types of pulmonary amyloidosis and their radiological appearances are described and discussed.
    Notes: Zusammenfassung Wir berichten über einen seltenen Fall einer pulmonalen nodulären Amyloidose mit allen typischen Merkmalen dieser Erkrankung bei gleichzeitigem Vorliegen von multiplen Amyloidomen mit Verkalkungen und zentralen Einschmelzungen. Die definitive Diagnose wurde histologisch mit einer CT-gesteuerten Biopsie gesichert. Die verschiedenen Formen der pulmonalen Amyloidose und deren radiologische Erscheinungsbilder werden beschrieben und diskutiert.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4943
    Keywords: Two-dimensional electrophoresis ; blotting ; amino acid analysis ; databases ; identification ; proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Mouse brain proteins were separated by two-dimensional electrophoresis (2-DE). The proteins of a section of the 2-DE pattern were blotted onto hydrophobic membranes and 43 of them were excised and hydrolyzed by liquid-phase hydrolysis. The amino acid composition of these proteins was determined by orthophthaldialdehyde precolumn derivatization and compared with the compositions of known proteins stored in the NBRF sequence database. An identification program named ASA was developed for this purpose. The ASA program includes correction and weighting factors, data reduction by molecular weight windows, and exclusion or inclusion of certain organisms as desired. As a control, eight test proteins and five well-known proteins from mouse brain, all separated by 2-DE, were correctly identified by the program. Out of the 43 brain proteins selected, 19 were identified with high confidence.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 30 (1992), S. 649-662 
    ISSN: 1573-4927
    Keywords: mouse ; reciprocal hybrids ; proteins ; two-dimensional electrophoresis ; genomic imprinting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two-dimensional electrophoretic patterns of cytoplasmic liver proteins of the mouse were investigated in reciprocal hybrids of the two inbred mouse strains DBA and C57BL in order to establish whether strain-specific protein variants reveal a mode of inheritance compatible with the concept of genomic imprinting. Variants of this type were found to account for about 11% of approximately 200 variant protein spots scrutinized. Transmission of the maternal form of a variant protein was more frequent than transmission of the paternal form. Maternal/paternal transmission was observed only for proteins showing strain variations in their amount. The results are discussed in terms of the frequency of imprinted genes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 30 (1992), S. 649-662 
    ISSN: 1573-4927
    Keywords: mouse ; reciprocal hybrids ; proteins ; two-dimensional electrophoresis ; genomic imprinting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two-dimensional electrophoretic patterns of cytoplasmic liver proteins of the mouse were investigated in reciprocal hybrids of the two inbred mouse strains DBA and C57BL in order to establish whether strain-specific protein variants reveal a mode of inheritance compatible with the concept of genomic imprinting. Variants of this type were found to account for about 11% of approximately 200 variant protein spots scrutinized. Transmission of the maternal form of a variant protein was more frequent than transmission of the paternal form. Maternal/paternal transmission was observed only for proteins showing strain variations in their amount. The results are discussed in terms of the frequency of imprinted genes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 356 (1982), S. 141-149 
    ISSN: 1435-2451
    Keywords: Acute pancreatitis ; Computed tomography ; Ultrasound ; Operative treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die „stadiengerechte Therapie” der akuten Pankreatitis, die jedem Schweregrad der Erkrankung angemessen ist, besteht neben der konservativen Basistherapie und Intensivmedizin im richtigen Einsatz operativer Maßnahmen. Voraussetzung dafür ist die frühe Diagnose und Beurteilung des Schweregrades der akuten Pankreatitis. Neben klinischen und klinisch-chemischen Befunden und dem Verlauf unter konservativer Therapie ermöglichen die Sonographie und die Computer-Tomographie eine bessere Beurteilung der jeweiligen Verlaufsform. Die für die Klinik der Erkrankung so wichtigen morphologischen Veränderungen der Bauchspeicheldrüse und ihrer Umgebung werden durch diese neuartigen Untersuchungsmethoden transparenter. Wäh rend bei der leichten Pankreatitis die Sonographie als erstes morphologisches Untersuchungsverfahren eingesetzt wird, besteht bei den schweren Verlaufsformen eine klassische Indikation zur Computer-Tomographie. Durch Einsatz von Sonographie und Computer-Tomographie läßt sich die Indikation zur frühzeitigen oder verzögerten Operation der hämorrhagisch-nekrotisierenden Pankreatitis, die bisher nach klinischen Kriterien erfolgte, in den meisten Fällen exakter stellen.
    Notes: Summary Adequate stage-depending therapy of acute pancreatitis includes basic conservative treatment, intensive care measurements, and operative interventions depending on the grade of severity. Prerequisites are early diagnosis and accurate clinical assessment of the stage of severity. Beside clinical and laboratory findings, as well as the development of acute pancreatitis under conservative treatment, sonography and computed tomography allow a better prediction of the underlying morphological changes, thus leading to an exact staging of the patient's individual situation. Sonography is regarded a screening procedure of high accuracy in mild forms of acute pancreatitis. Computed tomography is the method of choice in all severe forms of this disease. The indication for immediate or delayed operative treatment of hemorrhagic necrotising pancreatitis, heretofore depending on clinical findings solely, is supported by these new-invasive diagnostic modalities.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 802-802 
    ISSN: 1435-2451
    Keywords: Computed tomography ; Crohn's disease ; Ulcerative colitis ; Differential diagnosis ; Computertomographie ; Morbus Crohn ; Colitis ulcerosa ; Differentialdiagnose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seit 1981 wurden 109 Patienten mit Morbus Crohn und 31 Patienten mit Colitis ulcerosa prospektiv computertomographisch untersucht. Beim Nachweis colitis- und crohntypischer, extramucöser Befunde wie Fisteln, Abscesse, Darmwandverdickung und Mesenterialveränderungen war die CT der herkömmlichen radiologischen Diagnostik überlegen. Der hochfloriden Colitis ulcerosa und dem Colon-Crohn konnten computertomographisch typische Wandschichtungen zugeordnet werden, die in 4 von 6 unklaren Fällen mit reinem Colonbefall zur richtigen Diagnose führten. Der Stellenwert der CT in der präoperativen Abklärung und der Differentialdiagnose unklarer Colitiden wird unterstrichen.
    Notes: Summary Since 1981, 109 patients with Crohn's disease and 31 patients with ulcerative colitis have been investigated prospectively by computed tomography (CT). In the diagnosis of fistulas, abscesses, thickening of the bowel wall, and mesenteric pathology, CT was more sensitive than the usual radiological procedure. Pathognomonic layering of the bowel wall was demonstrated by CT in higly active ulcerative colitis and Crohn's disease of the colon. In 4 of 6 obscure cases of colitis, a clear distinction between Crohn's disease and ulcerative colitis was possible. The value of CT in preoperative assessment and differential diagnosis is to be emphasized.
    Type of Medium: Electronic Resource
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