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  • 1
    Electronic Resource
    Electronic Resource
    Structure-activity-relationships of someexo-isocamphanylcyclohexanols. Conformational calculations on sandalwood odour IX (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 747-752 
    Details
    ISSN: 1434-4475
    Keywords: Molecular shape ; molecular surface comparison ; Van der Waals surface ; Connolly surface ; Computer aided fragrance design ; sandalwood odour ; exo-isocamphanylcyclohexanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Geruchsunterschiede mehrererexo-Isocamphanylcyclohexanole werden durch den Vergleich der Molekülform erklärt. Mittels einer teilweisen Anpassung der molekularen Oberflächen werden die notwendigen strukturellen Bedingungen für den Sandelholzgeruch bestimmt.
    Notes: Summary The odour differences of variousexo-isocamphanylcyclohexanols are explained by molecular shape comparison. A partial matching of the molecular surfaces is used to evaluate necessary structural conditions for the Sandalwood scent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277636
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dopamine D2 receptor binding and cerebral glucose metabolism recover afterd-penicillamine-therapy in Wilson's disease (1994)
    Springer
    Journal of neurology 241 (1994), S. 577-584 
    Details
    ISSN: 1432-1459
    Keywords: Wilson's disease ; Positron emission tomography ; Dopamine D2 receptor ; Regional cerebral glucose metabolism ; Functional recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and18F-deoxyglucose and18F-methylspiperone ([18F]MSP), respectively. There was a severe reduction of striatal and extrastriatal rCMRGlc as well as of striatal [18F]MSP accumulation rate. After 1 year of treatment withd-penicillamine, striatal and extrastriatal rCMRGlc and striatal [18F]MSP accumulation rate reached almost normal levels. It is hypothesized that recovery of motor functions due to copper trapping therapy was associated with an increase in basal ganglia activity and a re-expression or upregulation of dopamine D2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00920620
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regional cerebral glucose consumption measured by positron emission tomography in patients with Wilson's disease (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 96-101 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Fluorodeoxyglucose F 18 ; Cerebral glucose consumption ; Movement disorders ; Wilson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using positron emission tomography (PET), the regional cerebral metabolic rate of glucose consumption (rCMRGlc) was measured in 14 patients with Wilson's disease (WD) and 23 normal subjects. In WD patients, cerebellar, striatal and — to a lesser extent — cortical and thalamic rCMRGIc were significantly decreased compared with controls. Striatal rCMRGIc was significantly reduced in those 4 patients who had recently started decoppering therapy as compared with striatal rCMRGlc measured in those 10 patients with longer duration of medication. Caudate rCMRGlc correlated significantly with various signs of extrapyramidal dysfunction. Cerebellar, thalamic and cortical rCMRGlc correlated significantly with the severity of pyramidal signs. These data indicate that the PET measurement of rCMRGIc may be a useful tool to evaluate cerebral involvement in WD and to monitor the response to treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184123
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    Paper (German National Licenses)
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