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  • 1
    Electronic Resource
    Electronic Resource
    Chromium bond detection in isolated erythrocytes: a new principle of biological monitoring of exposure to hexavalent chromium (1985)
    Springer
    International archives of occupational and environmental health 55 (1985), S. 305-318 
    Details
    ISSN: 1432-1246
    Keywords: Cr(III) compounds ; Cr(VI) compounds ; Conjugation of Cr(VI) compounds with erythrocytes ; Separation of erythrocytes ; Biological monitoring for Cr(VI)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Internal stress to chromium is only relevant in occupational medicine if it is due to the handling of hexavalent chromium. Cr(VI) ions, after uptake by inhalation or percutaneously are carried in the blood plasma and penetrate—depending on the concentration—into the erythrocytes. Due to the intracellular reduction to Cr(III) and the concurrent intracellular protein binding, the erythrocytes represent an easily accessible target organ for quantitative chromium determination after occupational exposure to Cr(VI) compounds. The results of an earlier experimental study indicate that human plasma too is capable of spontaneous reduction of Cr(VI) ions of up to 2 ppm to Cr(III). This plasma reduction capacity (PRC) can be increased and accelerated considerably by adding ascorbic acid (AA). These findings were supported in this investigation by proving a decreased binding of Cr(VI) inside the erythrocytes under the effect of AA. This leads to the assumption that only those Cr(VI) concentrations can penetrate the membrane of the erythrocytes and enter the cell which either come into contact with the membrane during the reduction process or exceed this limit concentration of 2 ppm. Only in these two instances can corresponding chromium findings be analyzed in isolated and washed erythrocytes. These results are compared with those obtained by conventional methods, such as Cr determination in the blood and/or urine. Our findings indicate that a single determination of chromium concentration in the erythrocytes will permit the monitoring of critical cases of Cr(VI) exposure. This is a new type of biological monitoring in the sense of a condensed longitudinal study, in order to find out whether threshold concentrations have been respected over a given period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00377689
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  • 2
    Electronic Resource
    Electronic Resource
    318. Die Duodenum erhaltende Pankreaskopfresektion bei chronischer Pankreatitis (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 616-616 
    Details
    ISSN: 1435-2451
    Keywords: Chronic pancreatitis ; Head resection ; Preservation of the duodenum ; Chronische Pankreatitis ; Pankreaskopfresektion ; Duodenumerhaltung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 15 Patienten mit chronischer Pankreatitis und Pankreaskopftumor wurde nach Malignomausschluß eine das Duodenum erhaltende Pankreaskopfresektion ausgeführt. Zur Überbrückung des Pankreasdefektes erfolgte Jejunuminterposition. Die Kliniksletalität war 0%. Nachbeobachtungszeit im Durchschnitt 31 Monate. 75% der Patienten waren wieder voll arbeitsfähig. Der Vorteil dieser Operation liegt im begrenzten Organtrauma, der Erhaltung der Duodenumpassage, Erhaltung des übrigen Pankreas für exound endokrine Funktion und Gewinnung des Pankreaskopftumors zur histologischen Beurteilung.
    Notes: Summary In 15 patients with chronic pancreatitis and a tumor of the head of the pancreas without malignancy, resection of the head of the pancreas preserving the duodenum was performed. For bridging the pancreas defect, jejunum is interposed. The clinical mortality was 0%. The follow-up time averages 31 months. 75% of the patients are completely restored. The benefit of this operation derives from the limited organ trauma, the protection of the duodenal passage, the protection of the remaining pancreas for the exo-endocrine functions and the presentation of the tumor of the pancreas for histological examinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292283
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    Paper (German National Licenses)
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