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  • 1
    Electronic Resource
    Electronic Resource
    Hair zinc of young children from rural and urban areas in North Rhine-Westphalia, Federal Republic of Germany (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 179-183 
    Details
    ISSN: 1432-1076
    Keywords: Zinc ; Hair ; North Rhine-Westphalia ; Atomic absorption spectrophotometry ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hair zinc levels were estimated by atomic absorption spectrophotometry in 474 children, aged 3–7 years, from 11 kindergartens in a highly industrialized and polluted area (Duisburg) and 8 kindergartens in a rural area of North Rhine-Westphalia. The mean hair zinc level amounted to 118 μg/g, increasing between the 4th and 7th year of life. At all ages the values from the urban toddlers were lower than from rural toddlers, and in both regions they were higher in winter than in summer. Children with frequent upper respiratory tract infections (〉6 infections/year) showed significantly lower zinc hair values, independent of their age. Low hair zinc values (below 70 μg/g) were frequently found, raising the question as to whether this is a normal, age-related phenomenon, or whether it indicates a suboptimal zinc status of young children from North Rhine-Westphalia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442218
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    γ/δ Receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis (1992)
    Springer
    Annals of hematology 65 (1992), S. 111-115 
    Details
    ISSN: 1432-0584
    Keywords: Interferon-γ ; Hematopoiesis ; γ/δ ; γ/δ T cells ; Cutaneous T-cell lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently we described a cutaneous T-cell lymphoma expressing the γ/δ T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a significant suppression of myeloid/monocyte colony formation (GM-CFU) compared with normal controls. This was not due to infiltration of the BM with lymphoma cells. We speculated that a soluble factor either secreted or induced by the lymphoma cells might be responsible for the marked suppression of hematopoiesis in this patient. From a skin biopsy with infiltrating γ/δ T-lymphoma cells we established T-cell clones bearing the γ/δ T-cell receptor and resembling the phenotype of the lymphoma cells. The supernatant (SN) of these γ/δ T-cell clones reduced the number of colonies in a CFU-GM assay (using normal control BM) in comparison to SN of α/β T-cell clones established from the same biopsy. This suppression was seen mainly on day 7 of culture and was not neutralized by the addition of placenta-CM. The main mediator of this suppression seems to be IFN-γ,since it was detectable in high amounts in the SN of these γ/δ T-cell tumor clones as well as in the serum of the patient. In addition, anti-IFN-γ antibodies can reverse the T-cell SN-mediated suppression of CFU-GM. We conclude that high serum levels of interferon-γ, which is secreted in high amounts from γ/δ T-cells grown from a biopsy of a cutaneous lymphoma, can suppress hematopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695808
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Variables influencing cadmium concentrations in hair of pre-school children living in different areas of the Federal Republic of Germany (1988)
    Springer
    International archives of occupational and environmental health 60 (1988), S. 43-50 
    Details
    ISSN: 1432-1246
    Keywords: Cadmium ; Hair ; Pre-school children ; Variables
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of several factors on cadmium (Cd) concentrations in the hair of 474 pre-school children was examined. The study was performed in an industrial (Duisburg) and rural area (Westfalen) of the (FRG). Season, sex, hair color, and place of residence were found to be the main factors influencing Cd levels in hair. Concentrations of Cd in samples obtained during summer were on the average nearly twice as high as those sampled during winter (geometric means: 116.1 vs. 63.7ng/g). Boys had more Cd in their hair than girls (111.5 vs.74.0 ng/g). Cd levels in hair decreased from red to blond, to brown, and black hair. Children living in Duisburg had more Cd in their hair than those from rural areas (103.9 vs.77.Ong/g). Cd content in hair was inversely related to age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409378
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    Paper (German National Licenses)
    Fulltext
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