ISSN:
1432-1440
Keywords:
Progressive multifokale Leukoenzephalopathie (PML)
;
Wegener'sche Granulomatose
;
Cyclosporin A (CyA)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A female patient with Wegener's granulomatosis developed severe bone marrow depression after two years treatment with cyclophosphamide. Corticosteroids alone could not sufficiently suppress disease activity, therefore additive therapy with Cyclosporin A was started. Four weeks later the patient developed a central nervous system disorder with affective disturbances and progressive somnolence. However, inspite of intensive diagnostic procedures, no definite diagnosis could be established. After another two months she died. Post-mortem-examination showed progressive multifocal leukoencephalopathy. An association between immunosuppressive therapy and reactivation of JC-Virus is suggested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01717330
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