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  • Cytochrome c oxidase deficiency  (1)
  • Parenchymal infiltration  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 679-681 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Myopathy ; Kearns-Sayre-syndrome ; Cytochrome c oxidase deficiency
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00334681
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Histopathological findings in the central and peripheral nervous systems in neuroborreliosis (1990)
    Springer
    Journal of neurology 237 (1990), S. 113-116 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Neuroborreliosis ; Vasculitis ; Parenchymal infiltration ; Axonal degeneration ; Monoclonal antibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314674
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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