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  • D-Met2, Pro5-enkephalinamide  (1)
  • Dexamethasone  (1)
  • Dopaminergic agonists  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man (1986)
    Springer
    Psychopharmacology 89 (1986), S. 409-413 
    Details
    ISSN: 1432-2072
    Keywords: Opiates ; Opioid peptides ; Enkephalin analogue ; Pain threshold ; Pain tolerance ; Cognitive functions ; Memory ; Attention ; D-Met2, Pro5-enkephalinamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects ofd-Met2, Pro5-enkephalinamide (EA) on pain tolerance and some cognitive functions have been examined in healthy male volunteers. Dihydrocodeine (DC) was used as reference substance. Applying the submaximum effort tourniquet technique EA (10 mg SC) was found to elevate the pain threshold similarly to DC (20 mg SC). Neither DC nor EA impaired the performance in the symbol cancellation test, which quantitates the intensity of attention. In this assay rather a slight improvement was detected. In addition the short-term memory performance (Wechsler test) was also improved by EA and DC. No alteration was seen in the word fluency test, an indicator of long-term (semantic) memory. The data show that EA not only improves pain tolerance but some of its mental effects are similar to those of a classical morphine congener DC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02412112
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of methysergide, bromocriptine and naloxone on prolactin, growth hormone and TSH release induced by d-Met2,Pro5-enkephalinamide in man (1986)
    Springer
    Psychopharmacology 88 (1986), S. 331-335 
    Details
    ISSN: 1432-2072
    Keywords: Opioid peptides ; d-Met2,Pro5-enkephalina-mide ; Prolactin ; Growth hormone ; TSH ; Methysergide ; Bromocriptine ; Dopaminergic agonists ; Serotonergic antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract d-Met2,Pro5-enkephalinamide (EA) 10 mg, given SC, induced a dramatic rise in serum prolactin (PRL) and growth hormone (GH) levels in healthy male volunteers. The TSH content was also moderately elevated. Naloxone 0.8 mg administered IV abolished these effects. Bromocriptine 2.5 mg given per os also antagonized EA-induced PRL and TSH release but potentiated the GH surge. Methysergide 2.0 mg administered orally partially reversed EA-elicited PRL release, further augmented GH liberation and did not modify TSH output. The data indicate that inhibition of the dopaminergic tone and/or activation of certain serotonergic mechanisms play an important role in the EA-induced release of PRL and TSH. However, primarily other neurotransmitters might mediate the GH liberation elicited by this opioid peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180834
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Measurement of interleukin-1 liberation in zymosan air-pouch exudate in mice (1994)
    Springer
    Inflammation research 41 (1994), S. 93-95 
    Details
    ISSN: 1420-908X
    Keywords: Interleukin-1 ; Zymosan air pouch ; Indomethacin ; Dexamethasone ; IX 207-887
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to examine whether interleukin-1 (IL-1) production is involved in the pathology of inflammation induced by zymosan in the air-pouch of mice. For this reason the IL-1α level was determined in the air-pouch exudate by specific ELISA kit 4, 24, 48 h and 4–8 days after zymosan injection into preformed subcutaneous air-pouches in mice. Concurrently, some conventional paremeters such as volume of exudate, its protein content and the total leukocyte count were also measured. The IL-1α level reached its maximum 24 h after zymosan administration and remained elevated throughout the 8-day observation period. Exudation, accumulation of leukocytes and protein also were maximal on day 8. The effects of some anti-inflammatory agents have also been examined. Orally administered dexamethasone induced a dose-dependent reduction in IL-1α, whereas indomethacin and IX 207–887, an IL-1-release inhibitor, failed to reduce the IL-1α content in this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986403
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    Paper (German National Licenses)
    Fulltext
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