ISSN:
1420-908X
Keywords:
Interleukin-1
;
Zymosan air pouch
;
Indomethacin
;
Dexamethasone
;
IX 207-887
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The aim of the present study was to examine whether interleukin-1 (IL-1) production is involved in the pathology of inflammation induced by zymosan in the air-pouch of mice. For this reason the IL-1α level was determined in the air-pouch exudate by specific ELISA kit 4, 24, 48 h and 4–8 days after zymosan injection into preformed subcutaneous air-pouches in mice. Concurrently, some conventional paremeters such as volume of exudate, its protein content and the total leukocyte count were also measured. The IL-1α level reached its maximum 24 h after zymosan administration and remained elevated throughout the 8-day observation period. Exudation, accumulation of leukocytes and protein also were maximal on day 8. The effects of some anti-inflammatory agents have also been examined. Orally administered dexamethasone induced a dose-dependent reduction in IL-1α, whereas indomethacin and IX 207–887, an IL-1-release inhibitor, failed to reduce the IL-1α content in this model.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01986403
