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  • 1
    Electronic Resource
    Electronic Resource
    IgA-Nephropathy (IgA-IgG-Nephropathy/IgA-Nephritis) — a disease entity? (1979)
    Springer
    Virchows Archiv 385 (1979), S. 1-27 
    Details
    ISSN: 1432-2307
    Keywords: IgA-Nephropathy ; Focal glomerulonephritis ; Mesangioproliferative glomerulonephritis ; Mesangium ; Hematuria ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 166 renal biopsies of 153 patients who showed the dominating mesangial IgA deposits of “IgA-Nephropathy”, relationships were established between immunohistologic, histologic and clinical findings with the following results: 1. The immunohistologic picture of IgA-Nephropathy exhibits a broad histologic spectrum including cases with histologically normal findings as well as mesangioproliferative Gn with focal and diffuse crescents. Most often the morphologic changes are associated with a mild and moderately severe mesangioproliferative Gn. 2. According to the extent of the morphologic lesions no discrepancy between immunohistologic and histologic findings exists. Excluding a few cases with a focal accentuation of the histologic picture the histologic lesions as well as the immunofluorescence pattern are diffuse. 3. The immunohistologic picture of IgA-Nephropathy cannot be associated with uniform and characteristic clinical and morphologic pictures. Therefore, the predominant mesangial IgA deposits of the IgA-Nephropathy-type should not be regarded as a clinical — morphologic entity but rather as a specific immunohistologic symptom with possible different underlying pathomechanisms, probably controlled by a common genetically determined aberrant immune response with in consequence various morphologic reactions of different intensity and with a relatively favorable prognosis in most cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433537
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  • 2
    Electronic Resource
    Electronic Resource
    Perimembranöse Glomerulonephritis nach Penicillamintherapie (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 835-837 
    Details
    ISSN: 1432-1440
    Keywords: D-Penicillamine ; peri(epi- extra)-membranous glomerulonephritis ; Immune-complex-nephritis ; drug side effects ; D-Penicillamin ; peri (epi- extra)-membranöse Glomerulonephritis ; Immunkomplexnephritis ; Arzneimittelnebenwirkungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über das Auftreten einer perimembranösen Glomerulonephritis bei 31 Patienten berichtet, die wegen verschiedener Grundleiden durchschnittlich 7 Monate lang Penicillamin (durchschnittlich 1 200 mg/Tag) erhalten hatten. Die perimembranöse Glomerulonephritis ging bei allen Patienten mit Proteinurie, bei 12 Patienten außerdem mit Hämaturie einher. Bei 8 Erkrankten entwickelte sich auch nach Absetzen der Therapie rasch, bei 12 allmählich ein nephrotisches Syndrom. Bei 5 Patienten mit nephrotischem Syndrom, die im Verlauf von 12 Monaten zweimal biopsiert werden konnten, war der Urin zur Zeit der 2. Biopsie eiweißfrei. Die für die perimembranöse Glomerulonephritis typischen Veränderungen an der Basalmembran der Glomerulumkapillaren mit subepithelialer bzw. intramembranöser Ablagerung von elektronendichten Depots hatten sich weitgehend zurückgebildet, wie durch vergleichende elektronenmikroskopische Untersuchungen nachgewiesen werden konnte.
    Notes: Summary This report includes 31 patients who developed a perimembranous glomerulonephritis generally 7 months after the onset of the treatment of various illnesses with D-Penicillamine. In all cases the patients had a proteinuria, associated with a hematuria in 12 cases. After the treatment was stopped 8 patients rapidly developed a nephrotic syndrome, while its onset was more gradual in 12 other patients. 5 patients initially with a nephrotic syndrome had no proteinuria at the time of a second biopsy made up to 12 months later. In these 5 cases the typical changes of perimembranous glomerulonephritis observed on electron microscopy were much reduced in the second biopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466756
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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