ISSN:
1432-2072
Keywords:
DL-308
;
Zetidoline
;
Performance tests
;
Subjective measurement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427573
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