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Digitale Medien

A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam (1983)

Herbert, M. ; Standen, P. J. ; Short, A. H. ; [weitere]

Springer

Psychopharmacology 81 (1983), S. 335-339

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Details

ISSN: 1432-2072

Schlagwort(e): DL-308 ; Zetidoline ; Performance tests ; Subjective measurement

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00427573

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