Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • DNA-antibodies-Systemic lupus erythematosus (SLE)  (1)
  • Hyperthyroidism, latent  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Significance of latent hyperthyroidism (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 543-550 
    Details
    ISSN: 1432-1440
    Keywords: Hyperthyroidism, latent ; TSH ; Circadian rhythm ; Pulsatile secretion ; Diagnostic methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In euthyroidism the circadian rhythm and pulsatility of TSH is well known. With regard to hyperthyroidism only very preliminary data were described. In this tudy we investigated the secretion pattern of the pituitary-thyroid axis hormones during 24 h in latent and overt hyperthyroidism and in euthyroidism with regard to common and different properties. Blood was obtained for 24 h at 10-min intervals. In euthyroidism we found intraindividually three overlapping patterns of TSH, which are different in amplitude and frequency and can be found interindividually, too. These patterns are equal to the circadian rhythm, pulsatile secretion and lastly to the methodic rustle. The circadian rhythm in latent hyperthyroidism is distinctly suppressed and in overt hyperthyroidism totally. Whereas in latent hyperthyroidism pulsatile secretion is extant, in overt hyperthyroidism the TSH pulses are absent. To record the patients' TSH circadian rhythm with only three blood samples, we defined the TSH-Triplex. In young as well as in elderly healthy volunteers it demonstrated significantly higher TSH levels at midnight (at 24:00 h) than it did at 4 p.m. and 8 a.m. The present study shows a significantly different TSH pattern in latent hyperthyroidism compared to euthyroidism. It should be discussed whether latent hyperthyroidism could be defined as hyperthyroidism stage I. On the other hand, latent hyperthyroidism could be an illness with its own cause, different from hyperthyroidism. Our data suggest that the laboratory findings of latent hyperthyroidism in each age are non-physiological. However, the cause for this disorder is unclear until now; hence further investigations are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719781
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Nachweis und Bedeutung antinucleärer Antikörper in der Diagnostik der Erkrankungen des rheumatischen Formenkreises (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 287-296 
    Details
    ISSN: 1432-1440
    Keywords: Antinuclear antibodies (ANA) ; DNA-antibodies-Systemic lupus erythematosus (SLE) ; Rheumatoid arthritis (RA) ; Connective tissue diseases ; Antinucleäre Faktoren (ANF) ; Anti-DNS-Antikörper ; Lupus erythematodes disseminatus (LED) ; Rheumatoide Arthritis (RA) ; Kollagenosen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Antinucleäre Antikörper und Anti-DNS-Antikörper wurden in den Seren von 60 Patienten, die an einem Lupus erythematodes disseminatus und 40 Patienten, die an einer rheumatoiden Arthritis erkrankt waren, bestimmt. Antinucleäre Faktoren ließen sich mit den verschiedenen Methoden in unterschiedlicher Häufigkeit und Titerhöhe nachweisen. Insgesamt wurden 9 verschiedene Untersuchungsmethoden für z.T. unterschiedliche Antikörperspezifitäten angewandt. Für die Anwendung in der Klinik erscheint eine Kombination verschiedener Techniken für die Diagnostik und Verlaufsbeobachtungen am ehesten geeignet, um neben dem pauschalen Nachweis der antinucleären Antikörper insgesamt einige spezifische Antikörperbefunde zu erfassen. Für Verlaufsbeobachtungen beim Lupus erythematodes disseminatus ist die radioimmunologische Bestimmung mit Hilfe eines Farr-Assays oder einer Doppelantikörpertechnik und wenn möglich simultaner Bestimmung der Antikörper gegen Einzelstrangund Doppelstrang-DNS am sinnvollsten.
    Notes: Summary Hundred ana-positive sera — 60 sera of SLE-patients and 40 sera of patients suffering from rheumatoid arthritis — were investigated for ana and DNA-antibodies. For these purposes nine different methods including several radioimmunological and immunofluorescence techniques with partially distinct antigen-specificities were tested. While the radioimmunoassays showed only slightly different results, significant differences in sensitivity as well as in antibody specificity existed mainly in the indirect immunofluorescence techniques using different substrates. For clinical use, a combination of various techniques seemed to be usefull i.e. indirect immunofluorescence on hemolysed bird erythrocytes and on frozen native rat liver sections. For DNA-antibodies in diagnosis and control during the course of the diseases the radioimmunoassay with simultaneous detection of antibodies to single-and double stranded DNA is most suitable. Antibodies to distinct nuclear antigens are detectable in various amount in the rheumatic diseases. While ds-DNA-antibodies seemed to be most specific for SLE, ss-DNA-antibodies occurred in nearly all ana-positive sera and seemed to be less specific for one disease than all the other ana-fractions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478208
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...