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  • 1
    Electronic Resource
    Electronic Resource
    Serial changes in endogenous erythropoietin levels in patients with myelodysplastic syndromes and aplastic anemia undergoing erythropoietin treatment (1993)
    Springer
    Annals of hematology 66 (1993), S. 175-180 
    Details
    ISSN: 1432-0584
    Keywords: Erythropoietin ; Myelodysplastic syndrome ; Aplastic anemia ; Serum erythropoietin concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recombinant human erythropoietin (rhEpo) was administered to 14 patients with myelodysplastic syndrome (MDS) and seven patients with aplastic anemia (AA). In 19 patients, doses of 6000 units were given intravenously three times a week (t.i.w.) with the dose being doubled up to 24000 units every 8 weeks until a response was obtained. RhEpo was given subcutaneously in two patients. Seven patients, four with MDS and three with AA, showed a significant response with an increase of hemoglobin concentration during therapy. The response occurred at doses of 12000 units in five and 24 000 units in two patients. Responding patients with both MDS and AA had a relatively low serum Epo (s-Epo) level prior to Epo therapy. MDS responders had either refractory anemia (RA) or RA with ring sideroblasts (RARS), while two of the Epo responders in AA had a severe form of the disease. However, since some of the Epo responders had a high initial s-Epo concentration, a high s-Epo level does not preclude the use of rhEpo. Serial determination of s-Epo levels showed a progressive decline in six of the seven responders even when they were on rhEpo therapy, while the s-Epo levels remained elevated or further increased with time in most nonresponders. RhEpo was well tolerated by all patients. The results suggest that rh-Epo is a safe and effective treatment for a certain proportion of patients with MDS and AA. Moreover, serial determination of s-Epo during therapy may be useful in monitoring and predicting the therapeutic effect of rhEpo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703232
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  • 2
    Electronic Resource
    Electronic Resource
    Investigation of physicochemical form of uranium in sediment of brackish Lake Obuchi using sequential extraction procedure (2000)
    Springer
    Limnology 1 (2000), S. 231-236 
    Details
    ISSN: 1439-863X
    Keywords: Key words Brackish Lake Obuchi ; Uranium ; Sediment ; Physicochemical form ; Sequential extraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The physicochemical form of uranium (238U) in the sediment of brackish Lake Obuchi was investigated using the standard procedures of sequential extraction. Approximately 60% to 70% of 238U was composed of the form bound to carbonates and iron (Fe)-manganese (Mn) oxides in silty sediments, whereas more than 50% of 238U existed in the minerals of sandy sediments. The proportions of 238U bound to carbonates in the sediments of brackish Lake Obuchi were larger than those in fresh-water lake sediments. Most of the uranium in the brackish lake sediment was considered to be mainly influenced by UO2(CO3)3 4− in seawater, judging from the fact that the 234U/ 238U activity ratios (1.13 to 1.16) of silty sediments were very close to that of seawater (1.14). The high correlation found between the 238U concentration in the sediment and the amount of organic matter demonstrated that organic matter acts as a scavenger for 238U accumulation on the lake bottom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s102010070011
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of fluctuations in salinity and water quality in brackish Lake Obuchi (2000)
    Springer
    Limnology 1 (2000), S. 57-62 
    Details
    ISSN: 1439-863X
    Keywords: Key words Brackish Lake Obuchi ; Salinity ; Water quality ; Density gradient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Fluctuations in the salinity and physicochemical characteristics of water quality were surveyed in brackish Lake Obuchi on the Shimokita Peninsula in Aomori, Japan. The mean salinity in the surface layer in all regions of Lake Obuchi was about 10 psu, whereas in the basin region at depths of greater than 3 m it was 20 psu. Furthermore, all the year round the halocline was formed at depths of 1–4 m. The maximum density gradient along a vertical axis in the center of the lake was observed at depths of 1–2 m in summer and 2–4 m in spring and fall. The depth of the maximum density gradient fluctuated with the seasons. In summer the water in the bottom layer was anoxic, and Fe, Mn, PO4 3−-P, and NH4 +-N supplied from the bottom sediment accumulated at high concentrations below the halocline. Thus, it was observed that the transfer of substances between the layers above and below the barrier formed by the halocline is suppressed. Although Lake Obuchi is small and shallow, the inflowing seawater easily resides, and a stable halocline readily forms because of the shape of its basin, which suddenly deepens on the Pacific Ocean side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s102010070029
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  • 4
    Electronic Resource
    Electronic Resource
    A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia (2000)
    Springer
    Journal of human genetics 45 (2000), S. 105-108 
    Details
    ISSN: 1435-232X
    Keywords: Key words Metaphyseal chondrodysplasia Schmid type (MCDS) ; Mutation ; Type X collagen gene (COL10A1) ; Carboxyl-terminal noncollagenous (NC1) domain ; Spondylometaphyseal dysplasia (SMD) ; Type X collagenopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Metaphyseal chondrodysplasia of the Schmid type (MCDS) is a skeletal dysplasia affecting the long bone metaphyses; it is characterized by short stature, bowlegs, and coxa vara. The spine is generally not involved. Here we report a novel missense mutation of the type X collagen gene in a sporadic case of MCDS. The mutation was a heterozygous single base-pair transition of G-to-A at nucleotide 1783, which predicted a substitution of glycine by arginine at codon 595 (G595R) in the carboxyl-terminal noncollagenous domain. Interestingly, another mutation of the same codon, in which glycine is substituted by glutamic acid (G595E), was previously reported to cause spondylometaphyseal dysplasia (SMD), another group of skeletal dysplasias with involvement of the spine in addition to the long tubular bones. The novel G595R mutation identified in the present study supports the concept of type X collagenopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050024
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    Paper (German National Licenses)
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