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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 191 (1993), S. 247-254 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Die Beziehungen zwischen der zeitlichen Veränderung der Charakteristika von Magmenquellen und der Öffnung des Japanischen Meeres werden anhand von Sr-Isotopendaten tertiärer und quartärer basaltischer Gesteine diskutiert. Basaltische Gesteine von der Grabenseite und aus der Übergangszone ergaben initiale87Sr/86Sr Verhältnisse (Sri-Verhältnisse) von 0.70411–0.70546 und lassen keine zeitabhängige Änderung erkennen. Basaltische Besteine aus dem Back-Arc-Bereich mit Altern zwischen 29.8 und ca. 15 Ma zeigen ähnliche Sri-Verhältnisse und ebenfalls keine zeitliche Veränderung. Im Gegensatz dazu sind basaltische Gesteine aus dem Back-Arc-Bereich, die jünger als ca. 15 Ma sind, signifikant in ihren Sri-Verhältnissen (0.70396–0.70290) erniedrigt. Diese Verhältnisse liegen etwas höher als die von N-MORB. Die Sr-Isotopenergebnisse lassen vermuten, daß zumindest vor ca. 15 Ma der Herkunftsbereich der Magmen (subkontinentaler Mantel) unter dem NE japanischen Vulkanbogen chemisch angereichert war, während die Magmenquellen der jüngeren vulkanischen Gesteine des Back-Arc-Bereiches durch eine drastische Abreicherung charakterisiert sind. Die abgereicherten Magmen könnten, während der Öffnung des japanischen Back-Arc-Beckens, als Folge der Injektion abgereicherter Asthenosphäre (oder eines abgereicherten Manteldiapirs) in subkontinentalen Mantel unterhalb des Back-Arcs des NE japanischen Vulkanbogens, gebildet worden sein. Die miozänen basaltischen Gesteine des Back-Arc-Bereiches sind außerdem durch niedrigere Gehalte an LIL-Elementen, wie z.B. K2O und Rb charakterisiert. Dies wird als Hinweis auf eine erhöhte Aufschmelzungsrate in diesem Bereich im mittleren Miozän (im Zuge der gleichzeitigen Öffnung des japanischen Meeres) verstanden. Die erhöhte Aufschmelzrate im Mantel des Back-Arc-Breiches wird auf einer Erhöhung des geothermischen Gradienten infolge der Injektion von heißer Asthenosphäre zurückgeführt. Diese Injektion von Asthenosphäre könnte auch der Grund für die Aufschmelzung von Unterkruste und für die Produktion weitverbreiteter saurer miozäner Vulkanite im Back-Arc-Bereich und der Übergangszone sein.
    Notes: Summary Based on Sr isotopic data for Tertiary and Quaternary basaltic rocks from the NE Japan arc, relationships are discussed between the temporal variation of magma source characteristics and the opening of the Japan Sea. The basaltic rocks from the trench side and from the transitional zone show initial87Sr/86Sr ratios (Sri ratios) in the range of 0.70411–0.70546 but no temporal variation in Sri ratios. The back-arc side basaltic rocks with ages of 29.8 to ≈ 15 Ma have Sri ratios similar to those of the trench side and the transitional zone, and these values also show no temporal change. In contrast, the basaltic rocks from the back-arc side, with ages younger than ≈ 15 Ma, show significantly lower Sri ratios (0.70396 to 0.70290), which are slightly higher than those of N-type MORB. These Sr isotopic features may imply that at least before ≈ 15 Ma the magma source regions (the sub-continental mantle) beneath the NE Japan arc had an enriched chemical character and that after ≈ 15 Ma, the magma sources for volcanic rocks from the back-arc side show a drastic change in Sr isotopic character, from an enriched nature to a depleted one. The depleted magmas may have been formed as a result of injection of depleted asthenosphere (or of a depleted mantle diapir) into the subcontinental mantle under the back-arc side of the NE Japan arc, during the spreading of the Japan Sea back-arc basin. The middle Miocene basaltic rocks from the back-arc side are characterized by lower contents of LIL elements such as K2O and Rb compared with those from the trench side, suggesting that during the middle Miocene (syn-opening stage of the Japan Sea) the degree of partial melting may have been higher in the back-arc side mantle than in the trench side mantle. High degree of partial melting in the back-arc side mantle can be attributed to an increasing geothermal gradient in the mantle due to the injection of hot asthenosphere. This injection might also have caused the melting of the lower crust from which the voluminous middle Miocene acidic volcanics in the back-arc side and transitional zone may have been produced.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0584
    Keywords: Erythropoietin ; Myelodysplastic syndrome ; Aplastic anemia ; Serum erythropoietin concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recombinant human erythropoietin (rhEpo) was administered to 14 patients with myelodysplastic syndrome (MDS) and seven patients with aplastic anemia (AA). In 19 patients, doses of 6000 units were given intravenously three times a week (t.i.w.) with the dose being doubled up to 24000 units every 8 weeks until a response was obtained. RhEpo was given subcutaneously in two patients. Seven patients, four with MDS and three with AA, showed a significant response with an increase of hemoglobin concentration during therapy. The response occurred at doses of 12000 units in five and 24 000 units in two patients. Responding patients with both MDS and AA had a relatively low serum Epo (s-Epo) level prior to Epo therapy. MDS responders had either refractory anemia (RA) or RA with ring sideroblasts (RARS), while two of the Epo responders in AA had a severe form of the disease. However, since some of the Epo responders had a high initial s-Epo concentration, a high s-Epo level does not preclude the use of rhEpo. Serial determination of s-Epo levels showed a progressive decline in six of the seven responders even when they were on rhEpo therapy, while the s-Epo levels remained elevated or further increased with time in most nonresponders. RhEpo was well tolerated by all patients. The results suggest that rh-Epo is a safe and effective treatment for a certain proportion of patients with MDS and AA. Moreover, serial determination of s-Epo during therapy may be useful in monitoring and predicting the therapeutic effect of rhEpo.
    Type of Medium: Electronic Resource
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