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  • d-Amphetamine  (2)
  • Desipramine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects ofd-amphetamine and methylphenidate on hyperactivity produced by neonatal 6-hydroxydopamine treatment (1989)
    Springer
    Psychopharmacology 99 (1989), S. 550-557 
    Details
    ISSN: 1432-2072
    Keywords: Neonatal ; 6-Hydroxydopamine ; Desipramine ; Amfolenic acid ; Dopamine ; d-Amphetamine ; Methylphenidate ; Hyperactivity ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neonatal intracisternal administration of 6-hydroxydopamine (6-OHDA, 50 μg on day 1 after birth) caused a marked hyperactivity when the rats were tested as adults. These rats also showed severe DA depletions in striatum and nucleus accumbens. Pretreatment with the noradrenaline (NA) uptake inhibitor desipramine provided protection against NA depletion in frontal cortex and nucleus accumbens. Pretreatment with DNA uptake inhibitors, amfolenic acid or GBR 12909, before 6-OHDA, provided full protection against DA depletion but produced marked NA depletion in frontal cortex. These rats did not demonstrate any degree of hyperactivity. Low doses ofd-amphetamine (0.25 mg/kg SC) or methylphenidate (1 mg/kg SC) reversed the hyperactivity in DA-depleted rats but increased motor activity in vehicle-treated and NA-depleted rats. Higher doses ofd-amphetamine (1 mg/kg) or methylphenidate (4 mg/kg) produced potentiated levels of locomotion but attenuated levels of rearing in DA-depleted animals. The results further suggest the utility of the neonatal DA lesion in rats as a potential animal model for derivation of therapeutic agents that may be efficacious in the treatment of the hyperkinetic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589907
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Central noradrenaline depletion antagonizes aspects ofd-amphetamine-induced hyperactivity in the rat (1986)
    Springer
    Psychopharmacology 88 (1986), S. 141-146 
    Details
    ISSN: 1432-2072
    Keywords: NA depletion ; d-Amphetamine ; DSP4 ; Neonatal 6-OHDA ; Adult 6-OHDA ; Dorsal mundle 6-OHDA ; DMI ; Hyperactivity ; Rearing ; Locomotion ; Dose ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of noradrenaline (NA) depletion upon amphetamine-induced hyperactivity were examined in five experiments. Central NA depletion via either systemic DSP4 or neonatal 6-OHDA antagonised the amphetamine-induced (2 mg/kg SC) increase in rearing behaviour, whereas lesions of the dorsal noradrenergic bundle using 6-hydroxydopamine antagonised the increase in locomotor activity. Peripheral NA depletion following systemic 6-hydroxydopamine to adult rats did not cause any changes in motor activity after acute amphetamine administration. Desipramine, the selective NA uptake inhibitor, blocked the effects of DSP4 upon amphetamine-induced rearing. NA depletion antagonised hyperactivity produced by the 2 mg/kg dose of amphetamine, but not the hyperactivity (rearing or locomotion) effects of amphetamine at 1, 4 or 8 mg/kg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652230
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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