ISSN:
1432-2072
Keywords:
NA depletion
;
d-Amphetamine
;
DSP4
;
Neonatal 6-OHDA
;
Adult 6-OHDA
;
Dorsal mundle 6-OHDA
;
DMI
;
Hyperactivity
;
Rearing
;
Locomotion
;
Dose
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of noradrenaline (NA) depletion upon amphetamine-induced hyperactivity were examined in five experiments. Central NA depletion via either systemic DSP4 or neonatal 6-OHDA antagonised the amphetamine-induced (2 mg/kg SC) increase in rearing behaviour, whereas lesions of the dorsal noradrenergic bundle using 6-hydroxydopamine antagonised the increase in locomotor activity. Peripheral NA depletion following systemic 6-hydroxydopamine to adult rats did not cause any changes in motor activity after acute amphetamine administration. Desipramine, the selective NA uptake inhibitor, blocked the effects of DSP4 upon amphetamine-induced rearing. NA depletion antagonised hyperactivity produced by the 2 mg/kg dose of amphetamine, but not the hyperactivity (rearing or locomotion) effects of amphetamine at 1, 4 or 8 mg/kg.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00652230
