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  • 1
    Electronic Resource
    Electronic Resource
    Activity of tuberoinfundibular dopaminergic neurons and concentrations of serum prolactin in the rat following lithium administration (1988)
    Springer
    Psychopharmacology 94 (1988), S. 92-96 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine ; Prolactin ; Lithium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Maintenance of rats on a lithium-containing diet for 3–21 days resulted in a suppression of prolactin (PRL) secretion in vivo and in vitro. Lithium treatment also resulted in an increase in the activity of tuberoinfundibular dopaminergic neurons, as evidenced by an increased accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after inhibition of DOPA decarboxylase and an increased concentration of dopamine in the anterior pituitary gland. The accumulation of DOPA in the neurointer-mediate lobe of the pituitary gland, the prefrontal cortex, the striatum and the nucleus accumbens was also enhanced by lithium treatment. It is concluded that lithium treatment enhances the synthesis of dopamine in many brain regions and that an increased activity of tuberoinfundibular dopaminergic neurons results in an enhanced inhibitory control of PRL secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735887
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of buspirone on rat plasma prolactin levels and striatal dopamine turnover (1982)
    Springer
    Psychopharmacology 78 (1982), S. 49-53 
    Details
    ISSN: 1432-2072
    Keywords: Prolactin ; Dopamine ; Buspirone ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Buspirone, an effective antianxiety compound, produced a dose-dependent, relatively prolonged increase in rat plasma prolactin (PRL) levels. The stimulation of PRL secretion by buspirone was additive with the effect of α-methyl-p-tyrosine (AMPT) or γ-butyrolactone. In vitro, buspirone itself had no effect on the release of PRL from rat pituitary glands but it blocked the inhibitory action of dopamine (DA). Buspirone also increased DA turnover in the striatum as measured by the AMPT-induced depletion of striatal DA levels. These results demonstrate the ability of buspirone to block pituitary and striatal DA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470587
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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