ISSN:
1432-1440
Keywords:
Drug resistance
;
Gastric emptying
;
H2-receptor antagonists
;
Motility
;
Ranitidine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary H2-receptor antagonists are known to fail to increase the intragastric pH in some patients (so-called non-responders), and we have recently found a higher frequency of non-responders among cirrhotics. Since intragastric pH is also affected by gastric emptying, in the present study we determined the gastric emptying of 300 ml orange juice labelled with [99mTc]-Solco Nanocoll using a gamma camera. Measurements were made over a period of 60 min in cirrhotic patients and controls without liver disease who either responded to 300 mg ranitidine or showed no response. The mean (±SD) liquid half-emptying time (T1/2) was 26.3±17.5 min (range, 9–75 min) in responders (n=10), 20.9±8.6 min (range, 7–34 min) in non-responders (n=10), 19.4±19.2 min (range, 7–75 min) in cirrhotics (n=11), and 27±4.6 min (range, 17–33 min) in controls (n=9). In 19 of the 20 subjects gastric emptying was normal (T 1/2, 〈40 min). Since gastric emptying was not delayed in any of the non-responders, it would appear very unlikely that gastric motility plays a major role in the non-response to H2-receptor antagonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01646654
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