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  • 1
    Electronic Resource
    Electronic Resource
    Neurovascular intact muscle transposition for anal sphincter repair (1995)
    Springer
    Diseases of the colon & rectum 38 (1995), S. 878-885 
    Details
    ISSN: 1530-0358
    Keywords: Dynamic anal sphincter repair ; Muscle fiber composition ; Muscle resting length ; Semitendinosus muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: To study muscle behavior for anal sphincter repair, radiologic, manometric, and histologic techniques in a dog animal model have been used. Special attention was given to the problem of resting length of the transposed muscle. METHODS: The semitendinosus muscle of the dog could be transposed successfully to create a new anal sphincter based on an intact neurovascular pedicle. The parallel-fibered muscle was split at its distal end and encircled around the anal canal. Manometry was performed intraoperatively and postoperatively. A sufficiently high basal and squeeze pressure had to be obtained intraoperatively to guarantee a final continent neosphincter. This could be realized by a progressive stretching of the muscle until maximum squeeze is reached. In one animal a pacemaker was implanted, and postoperatively a fixed sphincter stimulation protocol was started. Muscle biopsies of the normal anal sphincter and the neosphincter were taken. RESULTS: 1) Muscle transposition gave a high degree of continence in this experimental model, with a mean resting pressure of ±40 mmHg and a mean squeezing pressure of ±73 mmHg. 2) Electric stimulation of the neosphincter in one animal influenced the resting pressure but not the squeeze pressure. 3) Muscle fiber type composition changed toward a slow fiber type composition after transposition of the fast muscle and even more after stimulation. CONCLUSIONS: 1) Creation of a muscle cuff around the anal sphincter can substitute normal anal sphincter. 2) Adequate stretch of muscle fibers is essential for continence. 3) Electrical pacing helps preserve resting tension and subsequent continence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049846
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Peripheral primitive neuroectodermal tumour of the cervix (2000)
    Springer
    Virchows Archiv 436 (2000), S. 68-73 
    Details
    ISSN: 1432-2307
    Keywords: Key words Cervix ; Peripheral primitive neuroectodermal tumour ; Ewing’s tumour pathology ; Immunohistochemistry ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Peripheral primitive neuro-ectodermal tumours (PNET) of the cervix are very rare. Here, we report the clinical, pathological, immunohistochemical and genetic features of a case of a PNET located in the cervix. Hysterectomy revealed a cervical tumour. On microscopic examination, a vaguely lobular arrangement of uniformly appearing neoplastic cells, with round to oval nuclei, distinct nuclear membranes and a clear, moderately glycogen-rich cytoplasm was seen. Cells stained positive for LEU 7, S 100, monoclonal NSE and particularly for MIC2. Neurogenic differentiation was also seen by electron microscopic examination. The genetic hallmark of PNET, a 22q12 rearrangement was demonstrated by fluorescence in situ hybridisation experiments, supporting the diagnosis. Awareness of the existence of primary PNET of the cervix is important to avoid confusion with other tumours of the cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008201
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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