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  • 1
    Electronic Resource
    Electronic Resource
    Peripheral primitive neuroectodermal tumour of the cervix (2000)
    Springer
    Virchows Archiv 436 (2000), S. 68-73 
    Details
    ISSN: 1432-2307
    Keywords: Key words Cervix ; Peripheral primitive neuroectodermal tumour ; Ewing’s tumour pathology ; Immunohistochemistry ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Peripheral primitive neuro-ectodermal tumours (PNET) of the cervix are very rare. Here, we report the clinical, pathological, immunohistochemical and genetic features of a case of a PNET located in the cervix. Hysterectomy revealed a cervical tumour. On microscopic examination, a vaguely lobular arrangement of uniformly appearing neoplastic cells, with round to oval nuclei, distinct nuclear membranes and a clear, moderately glycogen-rich cytoplasm was seen. Cells stained positive for LEU 7, S 100, monoclonal NSE and particularly for MIC2. Neurogenic differentiation was also seen by electron microscopic examination. The genetic hallmark of PNET, a 22q12 rearrangement was demonstrated by fluorescence in situ hybridisation experiments, supporting the diagnosis. Awareness of the existence of primary PNET of the cervix is important to avoid confusion with other tumours of the cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008201
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  • 2
    Electronic Resource
    Electronic Resource
    Diagnosis of systemic candidiasis by enzyme immunoassay detection of specific antibodies to mycelial phase cell wall and cytoplasmic candidal antigens (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 839-846 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnosis of systemicCandida infections was attempted by the use of an enzyme-linked immunosorbent assay (EIA) to detect IgG antibodies towards cell wall-bound and cytoplasmic candidal antigens. Cell wall antigens were sequentially solubilized by treatment of germinated blastoconidia ofCandida albicans (ATCC 26555 strain) with β-mercaptoethanol (βME extract) and digestion with Zymolyase 20T, a β-glucanase preparation (Zymolyase extract). Protoplasts obtained after treatment with Zymolyase were osmotically lysed (cytoplasmic antigens). Sera were obtained from patients with systemic (n=28) and superficial (n=46) candidiasis. Control sera were obtained from normal healthy individuals (n=31) and from hospitalized patients at low (n=36) and at high (n=13) risk of developing systemic candidiasis yet showing no symptoms of candidal infection. Detection of antibodies in crude sera samples by EIA using all of these antigenic extracts was highly specific (98–100 %), but sensitivity of the method was low (3.5–17.8 %). However, adsorption of sera with latex microspheres coated with purifiedCandida mannan in order to selectively remove antimannan antibodies prior to EIA improved the diagnostic efficiency of this test. Improvement was particularly noticeable when the βME extract was used as antigenic preparation, yielding a sensitivity of 89.2 % and a specificity of 98.6 %.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02000404
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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