ISSN:
1573-2568
Keywords:
SYSTEMIC SCLEROSIS
;
ESOPHAGEAL PH
;
ESOPHAGEAL MOTILITY
;
ESOPHAGEAL CLEARANCE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Incidental clinical observations suggest thatbuffering substances may accumulate in the distalesophagus of patients with systemic sclerosis. The aimof our study was to assess if the buffering capacity of the intraesophageal milieu is increased inpatients with systemic sclerosis and if this effect canbe correlated to some pathophysiological aspects of thedisease. We recorded intraesophageal pH before and during a 10-min intraesophageal infusion ofacid (HCl 0.01 N, 1 ml/min), as well as esophagealmotility and clearance function, in 16 patients withsystemic sclerosis and 10 healthy subjects. Esophageal buffering capacity expressed as the area underthe curve of intraesophageal pH during acid infusion wassignificantly higher in the patients than in thecontrols, and this variable was directly correlated with esophageal clearing time. In conclusion,esophageal buffering capacity is increased in patientswith systemic sclerosis and is possibly the consequenceof the accumulation of buffering substances in the distal esophagus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026656220075
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